Defining physiological normoxia for improved translation of cell physiology to animal models and humans

TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

What is the concentration of hydrogen peroxide in blood and plasma?

HJ Forman, A Bernardo, KJA Davies - Archives of biochemistry and …, 2016 - Elsevier
The concentration of hydrogen peroxide (H 2 O 2) in blood and plasma is a measurement
that has often been made, but the absolute values remain unsettled due the great variability …

Inflammation in sickle cell disease

N Conran, JD Belcher - Clinical hemorheology and …, 2018 - content.iospress.com
The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

[图书][B] Handbook of food science, technology, and engineering

YH Hui - 2006 - books.google.com
Handbook of food science, technology, and engineering Page 1 HANDBOOK of FOOD
SCIENCE, TECHNOLOGY, AND ENGINEERING Volume 4 Edited by YH HUI Associate Editors …

The rate of oxygen utilization by cells

BA Wagner, S Venkataraman, GR Buettner - Free Radical Biology and …, 2011 - Elsevier
The discovery of oxygen is considered by some to be the most important scientific discovery
of all time—from both physical–chemical/astrophysics and biology/evolution viewpoints. One …

Catalase enzyme mutations and their association with diseases

L Góth, P Rass, A Páy - Molecular Diagnosis, 2004 - Springer
Enzyme catalase seems to be the main regulator of hydrogen peroxide metabolism.
Hydrogen peroxide at high concentrations is a toxic agent, while at low concentrations it …

Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte

FM Low, MB Hampton, AV Peskin, CC Winterbourn - Blood, 2007 - ashpublications.org
Abstract Peroxiredoxin 2 (Prx2), a thiol-dependent peroxidase, is the third most abundant
protein in the erythrocyte, and its absence in knock-out mice gives rise to hemolytic anemia …

Direct Evidence for Catalase as the Predominant H2O2 -Removing Enzyme in Human Erythrocytes

S Mueller, HD Riedel… - Blood, The Journal of the …, 1997 - ashpublications.org
Decomposition of hydrogen peroxide (H2O2) at physiological levels was studied in human
erythrocytes by means of a recently developed sensitive H2O2 assay. The exponential …

Cerebrovascular inflammation following subarachnoid hemorrhage

R Sercombe, YRT Dinh, P Gomis - The Japanese Journal of …, 2002 - jstage.jst.go.jp
Aneurysmal subarachnoid hemorrhage frequently results in complications including
intracranial hypertension, rebleeding and vasospasm. The extravasated blood is …

Iron and dioxygen chemistry is an important route to initiation of biological free radical oxidations: an electron paramagnetic resonance spin trapping study

SY Qian, GR Buettner - Free radical biology and medicine, 1999 - Elsevier
Iron can be a detrimental catalyst in biological free radical oxidations. Because of the high
physiological ratio of [O2]/[H2O2](≥ 103), we hypothesize that the Fenton reaction with pre …