[HTML][HTML] Drug repurposing for cancer therapy
Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …
health. Despite significant advances in surgical, radiotherapeutic and immunological …
[HTML][HTML] The role of Hedgehog signaling pathway in head and neck squamous cell carcinoma
P Cierpikowski, A Leszczyszyn, J Bar - Cells, 2023 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …
[HTML][HTML] Drug Selection and Posology, Optimal Therapies and Risk/Benefit Assessment in Medicine: The Paradigm of Iron-Chelating Drugs
GJ Kontoghiorghes - International Journal of Molecular Sciences, 2023 - mdpi.com
The design of clinical protocols and the selection of drugs with appropriate posology are
critical parameters for therapeutic outcomes. Optimal therapeutic protocols could ideally be …
critical parameters for therapeutic outcomes. Optimal therapeutic protocols could ideally be …
[HTML][HTML] Metronomic chemotherapy and drug repurposing: A paradigm shift in oncology
Cancer represents a significant global health and economic burden due to its high mortality
rates. While effective in some instances, traditional chemotherapy often falls short of entirely …
rates. While effective in some instances, traditional chemotherapy often falls short of entirely …
Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies
NS Kiran, C Yashaswini, R Maheshwari… - ACS Pharmacology & …, 2024 - ACS Publications
Precision medicine is transforming colorectal cancer treatment through the integration of
advanced technologies and biomarkers, enhancing personalized and effective disease …
advanced technologies and biomarkers, enhancing personalized and effective disease …
[HTML][HTML] Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies
Autophagy is a globally conserved cellular activity that plays a critical role in maintaining
cellular homeostasis through the breakdown and recycling of cellular constituents. In recent …
cellular homeostasis through the breakdown and recycling of cellular constituents. In recent …
Mechanistic insights into medulloblastoma relapse
K Peterson, M Turos-Cabal, AD Salvador… - Pharmacology & …, 2024 - Elsevier
Pediatric brain tumors are the leading cause of cancer-related deaths in children, with
medulloblastoma (MB) being the most common type. A better understanding of these …
medulloblastoma (MB) being the most common type. A better understanding of these …
[HTML][HTML] Quinazolines and thiazolidine-2, 4-dions as SARS-CoV-2 inhibitors: repurposing, in silico molecular docking and dynamics simulation
This paper presents an extensive analysis of COVID-19 with a specific focus on VEGFR-2
inhibitors as potential treatments. The investigation includes an overview of computational …
inhibitors as potential treatments. The investigation includes an overview of computational …
In-vitro and in-silico analysis and antitumor studies of novel Cu (II) and V (V) complexes of Np-Tolylbenzohydroxamic acid
M Tripathi, Y Thakur, R Syed, AK Asatkar… - International Journal of …, 2024 - Elsevier
Copper (L 2 Cu) and vanadium (L 2 VOCl) complexes of Np-tolylbenzohydroxamic acid (LH)
ligand have been investigated for DNA binding efficacy by multiple analytical, spectral, and …
ligand have been investigated for DNA binding efficacy by multiple analytical, spectral, and …
[HTML][HTML] Stem cell technology for antitumor drug loading and delivery in oncology
F Petrella, EM Cassina, L Libretti, E Pirondini… - Oncology …, 2024 - ncbi.nlm.nih.gov
The main aim of antineoplastic treatment is to maximize patient benefit by augmenting the
drug accumulation within affected organs and tissues, thus incrementing drug effects and, at …
drug accumulation within affected organs and tissues, thus incrementing drug effects and, at …