Myc is an oncogene deregulated in most—perhaps all—human cancers. Each Myc family
member, c-, L-, and N-Myc, has been connected to tumor progression and maintenance …

The intestinal epithelium is a multicellular interface in close proximity to a dense microbial
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …

The transcription factor MYC (MYC proto-oncogene, bHLH transcription factor) is an
essential signaling hub in multiple cellular processes that sustain growth of many types of …

The outstretched applications of biosensors in diverse domains has become the reason for
their attraction for scientific communities. Because they are analytical devices, they can …

Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …

Here we ask: What is productive signaling? How to define it, how to measure it, and most of
all, what are the parameters that determine it? Further, what determines the strength of …

Basal-like/triple-negative breast cancers (TNBCs) are among the most aggressive forms of
breast cancer, and disproportionally affects young premenopausal women and women of …

About one-half of all Burkitt lymphoma (BL) patients are younger than 40 years, and one-
third belong to the adolescent and young adult (AYA) subset, defined by an age between 15 …

The mitochondrion is a major hub of cellular metabolism and involved directly or indirectly in
almost all biological processes of the cell. In mitochondrial diseases, compromised …

The MYC oncoprotein functions as a master regulator of cellular transcription and executes
non-transcriptional tasks relevant to DNA replication and cell cycle regulation, thereby …