[HTML][HTML] Oxidative stress: a suitable therapeutic target for optic nerve diseases?
F Buonfiglio, EW Böhm, N Pfeiffer, A Gericke - Antioxidants, 2023 - mdpi.com
Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …
[HTML][HTML] Oxidative stress in the brain and retina after traumatic injury
The brain and the retina share many physiological similarities, which allows the retina to
serve as a model of CNS disease and disorder. In instances of trauma, the eye can even …
serve as a model of CNS disease and disorder. In instances of trauma, the eye can even …
[HTML][HTML] Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies
M Guo, Y Zhu, Y Shi, X Meng, X Dong, H Zhang… - Redox biology, 2022 - Elsevier
Retinal ganglion cell (RGC) death is a hallmark of traumatic optic neuropathy, glaucoma,
and other optic neuropathies that result in irreversible vision loss. However, therapeutic …
and other optic neuropathies that result in irreversible vision loss. However, therapeutic …
[HTML][HTML] Subtype-specific survival and regeneration of retinal ganglion cells in response to injury
ML Tapia, G Nascimento-dos-Santos… - Frontiers in cell and …, 2022 - frontiersin.org
Retinal ganglion cells (RGCs) are a heterogeneous population of neurons that function
synchronously to convey visual information through the optic nerve to retinorecipient target …
synchronously to convey visual information through the optic nerve to retinorecipient target …
Hippocampal-dependent cognitive dysfunction following repeated diffuse rotational brain injury in male and female mice
Cognitive dysfunction is a common, often long-term complaint following acquired traumatic
brain injury (TBI). Cognitive deficits suggest dysfunction in hippocampal circuits. The goal of …
brain injury (TBI). Cognitive deficits suggest dysfunction in hippocampal circuits. The goal of …
[HTML][HTML] Diffusion basis spectrum imaging detects subclinical traumatic optic neuropathy in a closed-head impact mouse model of traumatic brain injury
Introduction Traumatic optic neuropathy (TON) is the optic nerve injury secondary to brain
trauma leading to visual impairment and vision loss. Current clinical visual function …
trauma leading to visual impairment and vision loss. Current clinical visual function …
Construction and analysis of mRNA, lncRNA, and transcription factor regulatory networks after retinal ganglion cell injury
N Yang, J Yang, X He, W Zhang, Y Xing - Experimental Eye Research, 2022 - Elsevier
Retinal ganglion cell (RGC) injury is a critical pathological feature of several optic
neurodegenerative diseases. The regulatory mechanisms underlying RGC injury remain …
neurodegenerative diseases. The regulatory mechanisms underlying RGC injury remain …
[HTML][HTML] The outcome of surgical and non-surgical treatments for traumatic optic neuropathy: a comparative study of 685 cases
W Wei, SF Zhao, Y Li, JL Zhang, JP Wu… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background The choice and efficacy of surgical or/and surgical treatments for traumatic optic
neuropathy (TON) remained controversial by now. This study aims to present the outcomes …
neuropathy (TON) remained controversial by now. This study aims to present the outcomes …
Application of electrostimulation and magnetic stimulation in patients with optic neuropathy: A mechanistic review
MR Khalili, A Shadmani… - Developmental …, 2024 - Wiley Online Library
Visual impairment caused by optic neuropathies is irreversible because retinal ganglion
cells (RGCs), the specialized neurons of the retina, do not have the capacity for self‐renewal …
cells (RGCs), the specialized neurons of the retina, do not have the capacity for self‐renewal …
[HTML][HTML] Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact
A Kwok, B Chaqour, RS Khan… - … Vision Science & …, 2024 - tvst.arvojournals.org
Purpose: Resveratrol (RSV) is a nutraceutical compound known for its therapeutic potential
in neurodegenerative and metabolic diseases. RSV promotes survival signals in retinal …
in neurodegenerative and metabolic diseases. RSV promotes survival signals in retinal …