[HTML][HTML] Oxidative stress: a suitable therapeutic target for optic nerve diseases?

F Buonfiglio, EW Böhm, N Pfeiffer, A Gericke - Antioxidants, 2023 - mdpi.com
Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …

[HTML][HTML] Oxidative stress in the brain and retina after traumatic injury

AK Ryan, W Rich, MA Reilly - Frontiers in neuroscience, 2023 - frontiersin.org
The brain and the retina share many physiological similarities, which allows the retina to
serve as a model of CNS disease and disorder. In instances of trauma, the eye can even …

[HTML][HTML] Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies

M Guo, Y Zhu, Y Shi, X Meng, X Dong, H Zhang… - Redox biology, 2022 - Elsevier
Retinal ganglion cell (RGC) death is a hallmark of traumatic optic neuropathy, glaucoma,
and other optic neuropathies that result in irreversible vision loss. However, therapeutic …

[HTML][HTML] Subtype-specific survival and regeneration of retinal ganglion cells in response to injury

ML Tapia, G Nascimento-dos-Santos… - Frontiers in cell and …, 2022 - frontiersin.org
Retinal ganglion cells (RGCs) are a heterogeneous population of neurons that function
synchronously to convey visual information through the optic nerve to retinorecipient target …

Hippocampal-dependent cognitive dysfunction following repeated diffuse rotational brain injury in male and female mice

LB Tucker, AH Fu, JT McCabe - Journal of neurotrauma, 2021 - liebertpub.com
Cognitive dysfunction is a common, often long-term complaint following acquired traumatic
brain injury (TBI). Cognitive deficits suggest dysfunction in hippocampal circuits. The goal of …

[HTML][HTML] Diffusion basis spectrum imaging detects subclinical traumatic optic neuropathy in a closed-head impact mouse model of traumatic brain injury

HC Yang, RS Lavadi, AD Sauerbeck… - Frontiers in …, 2023 - frontiersin.org
Introduction Traumatic optic neuropathy (TON) is the optic nerve injury secondary to brain
trauma leading to visual impairment and vision loss. Current clinical visual function …

Construction and analysis of mRNA, lncRNA, and transcription factor regulatory networks after retinal ganglion cell injury

N Yang, J Yang, X He, W Zhang, Y Xing - Experimental Eye Research, 2022 - Elsevier
Retinal ganglion cell (RGC) injury is a critical pathological feature of several optic
neurodegenerative diseases. The regulatory mechanisms underlying RGC injury remain …

[HTML][HTML] The outcome of surgical and non-surgical treatments for traumatic optic neuropathy: a comparative study of 685 cases

W Wei, SF Zhao, Y Li, JL Zhang, JP Wu… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background The choice and efficacy of surgical or/and surgical treatments for traumatic optic
neuropathy (TON) remained controversial by now. This study aims to present the outcomes …

Application of electrostimulation and magnetic stimulation in patients with optic neuropathy: A mechanistic review

MR Khalili, A Shadmani… - Developmental …, 2024 - Wiley Online Library
Visual impairment caused by optic neuropathies is irreversible because retinal ganglion
cells (RGCs), the specialized neurons of the retina, do not have the capacity for self‐renewal …

[HTML][HTML] Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact

A Kwok, B Chaqour, RS Khan… - … Vision Science & …, 2024 - tvst.arvojournals.org
Purpose: Resveratrol (RSV) is a nutraceutical compound known for its therapeutic potential
in neurodegenerative and metabolic diseases. RSV promotes survival signals in retinal …