Update on the transdifferentiation of pancreatic cells into functional beta cells for treating diabetes
R Spezani, PH Reis-Barbosa… - Life Sciences, 2024 - Elsevier
The increasing global prevalence and associated comorbidities need innovative
approaches for type 2 diabetes mellitus (T2DM) prevention and treatment. Genetics …
approaches for type 2 diabetes mellitus (T2DM) prevention and treatment. Genetics …
Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system
S Sasaki, MYY Lee, Y Wakabayashi, L Suzuki… - Diabetologia, 2022 - Springer
Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine
progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and …
progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and …
Chronology of endocrine differentiation and beta-cell neogenesis
T Miyatsuka - Endocrine Journal, 2016 - jstage.jst.go.jp
Diabetes is a chronic and incurable disease, which results from absolute or relative insulin
insufficiency. Therefore, pancreatic beta cells, which are the only type of cell that expresses …
insufficiency. Therefore, pancreatic beta cells, which are the only type of cell that expresses …
Suppression of STAT3 signaling promotes cellular reprogramming into insulin-producing cells induced by defined transcription factors
M Miura, T Miyatsuka, T Katahira, S Sasaki, L Suzuki… - …, 2018 - thelancet.com
Background STAT3 has been demonstrated to play a role in maintaining cellular identities in
the pancreas, whereas an activating STAT3 mutation has been linked to impaired β-cell …
the pancreas, whereas an activating STAT3 mutation has been linked to impaired β-cell …
Genetic ablation of p62/SQSTM1 demonstrates little effect on pancreatic β-cell function under autophagy deficiency
T Fukae, T Miyatsuka, M Himuro… - Biochemical and …, 2022 - Elsevier
Autophagy is known to play an essential role in intracellular quality control through the
degradation of damaged organelles and components. We previously demonstrated that β …
degradation of damaged organelles and components. We previously demonstrated that β …
Spatial and transcriptional heterogeneity of β-cell neogenesis revealed by a time-resolved reporter system
S Sasaki, M Lee, Y Wakabayashi, L Suzuki, H Winata… - 2020 - researchsquare.com
While pancreatic β cells have been shown to originate from endocrine progenitors in ductal
regions, it remains unclear precisely where β cells emerge and which transcripts define …
regions, it remains unclear precisely where β cells emerge and which transcripts define …
Suppression of STAT3 signaling promotes cellular reprogramming into insulinproducing cells induced by defined transcription factors
三浦正樹， ミウラマサキ - 2017 - jair.repo.nii.ac.jp
Masaki Miura a, Takeshi Miyatsuka a, b,⁎, Takehiro Katahira a, Shugo Sasaki c, Luka
Suzuki a, Miwa Himuro a, Yuya Nishida a, Yoshio Fujitani a, d, Taka-aki Matsuoka c,⁎ …
Suzuki a, Miwa Himuro a, Yuya Nishida a, Yoshio Fujitani a, d, Taka-aki Matsuoka c,⁎ …
5. 膵β 細胞再生研究の最前線
宮塚健， 佐々木周伍 - 糖尿病, 2018 - jstage.jst.go.jp
全ての糖尿病患者は膵 β 細胞数が質的あるいは量的に低下した 「β 細胞不全」 を合併する.
よって糖尿病の根治を目指すためには, 血糖値を正常範囲に制御するのに充分なだけの β …
よって糖尿病の根治を目指すためには, 血糖値を正常範囲に制御するのに充分なだけの β …