The impermeable barrier of solid tumors due to the complexity of their components limits the
treatment effect of nanomedicine and hinders its clinical translation. Several methods are …

Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …

Determining the migratory and invasive capacity of tumor and stromal cells and clarifying the
underlying mechanisms is most relevant for novel strategies in cancer diagnosis, prognosis …

Cancers are complex and heterogeneous pathological “organs” in a dynamic interplay with
their host. Models of human cancer in vitro, used in cancer biology and drug discovery, are …

Abstract Three-dimensional (3D) in vitro models have been used in cancer research as an
intermediate model between in vitro cancer cell line cultures and in vivo tumor. Spherical …

Although used in academic research for several decades, 3D culture models have long
been regarded expensive, cumbersome and unnecessary in drug development processes …

Novel microfluidic tools allow new ways to manufacture and test drug delivery systems.
Organ-on-a-chip systems—microscale recapitulations of complex organ functions—promise …

Invasion and dissemination of well-differentiated carcinomas are often associated with loss
of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor cells at the …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

Over the past few years, establishment and adaptation of cell-based assays for drug
development and testing has become an important topic in high-throughput screening …