Common causes of hearing loss in humans-exposure to loud noise or ototoxic drugs and
aging-often damage sensory hair cells, reflected as elevated thresholds on the clinical …

Tinnitus is the conscious perception of a sound without a corresponding external acoustic
stimulus, usually described as a phantom perception. One of the major challenges for …

Recent work suggests that hair cells are not the most vulnerable elements in the inner ear;
rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate …

The classic view of sensorineural hearing loss (SNHL) is that the “primary” targets are hair
cells, and that cochlear-nerve loss is “secondary” to hair cell degeneration. Our recent work …

Cochlear synaptic loss, rather than hair cell death, is the earliest sign of damage in both
noise-and age-related hearing impairment (;). Here, we compare cochlear aging after two …

Background The most common form of tinnitus is a subjective, auditory, and distressing
phantom phenomenon. Comorbidity with depression is high but other important psychiatric …

Subjective tinnitus is the conscious perception of sound in the absence of any acoustic
source. The literature suggests various tinnitus mechanisms, most of which invoke changes …

Adaptation is an essential feature of auditory neurons, which reduces their responses to
unchanging and recurring sounds and allows their response properties to be matched to the …

The majority of tinnitus patients are affected by chronic idiopathic tinnitus, and almost 60
different treatment modalities have been reported. The present study is a multidisciplinary …

Objectives: Permanent threshold elevation after noise exposure, ototoxic drugs, or aging is
caused by loss of sensory cells; however, animal studies show that hair cell loss is often …