Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …
continues to afflict hundreds of millions of people every year. Infections with malaria …
[HTML][HTML] Immune mechanisms in malaria: new insights in vaccine development
EM Riley, VA Stewart - Nature medicine, 2013 - nature.com
Early data emerging from the first phase 3 trial of a malaria vaccine are raising hopes that a
licensed vaccine will soon be available for use in endemic countries, but given the relatively …
licensed vaccine will soon be available for use in endemic countries, but given the relatively …
[HTML][HTML] Pathogenesis of cerebral malaria—inflammation and cytoadherence
J Storm, AG Craig - Frontiers in cellular and infection microbiology, 2014 - frontiersin.org
Despite decades of research on cerebral malaria (CM) there is still a paucity of knowledge
about what actual causes CM and why certain people develop it. Although sequestration of …
about what actual causes CM and why certain people develop it. Although sequestration of …
Cerebral malaria
AL Luzolo, DM Ngoyi - Brain research bulletin, 2019 - Elsevier
Malaria remains of significant public health concern under the tropics, causing millions of
deaths annually. The disease is caused by protozoans of the Plasmodium genus, of which …
deaths annually. The disease is caused by protozoans of the Plasmodium genus, of which …
Hemoglobins S and C Interfere with Actin Remodeling in Plasmodium falciparum–Infected Erythrocytes
The hemoglobins S and C protect carriers from severe Plasmodium falciparum malaria.
Here, we found that these hemoglobinopathies affected the trafficking system that directs …
Here, we found that these hemoglobinopathies affected the trafficking system that directs …
Cerebral malaria is associated with differential cytoadherence to brain endothelial cells
J Storm, JS Jespersen, KB Seydel… - EMBO Molecular …, 2019 - embopress.org
Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …
[HTML][HTML] G-quadruplexes: more than just a kink in microbial genomes
N Saranathan, P Vivekanandan - Trends in microbiology, 2019 - cell.com
G-quadruplexes (G4s) are noncanonical nucleic acid secondary structures formed by
guanine-rich DNA and RNA sequences. In this review we aim to provide an overview of the …
guanine-rich DNA and RNA sequences. In this review we aim to provide an overview of the …
[HTML][HTML] Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?
The sequestration of Plasmodium falciparum–infected red blood cells (irbcs) in the
microvasculature of organs is associated with severe disease; correspondingly, the …
microvasculature of organs is associated with severe disease; correspondingly, the …
[HTML][HTML] Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA
R Ma, T Lian, R Huang, JP Renn, JD Petersen… - Nature …, 2021 - nature.com
Plasmodium falciparum VAR2CSA binds to chondroitin sulfate A (CSA) on the surface of the
syncytiotrophoblast during placental malaria. This interaction facilitates placental …
syncytiotrophoblast during placental malaria. This interaction facilitates placental …
[HTML][HTML] Emerging biology of noncoding RNAs in malaria parasites
In eukaryotic organisms, noncoding RNAs (ncRNAs) have been implicated as important
regulators of multifaceted biological processes, including transcriptional, posttranscriptional …
regulators of multifaceted biological processes, including transcriptional, posttranscriptional …