[HTML][HTML] A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine
S Moghadasi, M Elveny, HS Rahman… - Journal of translational …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-
apoptotic, and immunoregulatory competencies along with fewer ethical issues are …
apoptotic, and immunoregulatory competencies along with fewer ethical issues are …
[HTML][HTML] Extracellular vesicles in kidney disease
C Grange, B Bussolati - Nature Reviews Nephrology, 2022 - nature.com
Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …
They function as a long-distance cell-to-cell communication mechanism that modulates the …
Prevalence and disease burden of chronic kidney disease
JC Lv, LX Zhang - Renal fibrosis: mechanisms and therapies, 2019 - Springer
Chronic kidney disease (CKD) has been recognized as a leading public health problem
worldwide. The global estimated prevalence of CKD is 13.4%(11.7–15.1%), and patients …
worldwide. The global estimated prevalence of CKD is 13.4%(11.7–15.1%), and patients …
[HTML][HTML] Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury
JY Cao, B Wang, TT Tang, Y Wen, ZL Li, ST Feng… - Theranostics, 2021 - ncbi.nlm.nih.gov
Mesenchymal stem cells-derived exosomes (MSC-exos) have attracted great interest as a
cell-free therapy for acute kidney injury (AKI). However, the in vivo biodistribution of MSC …
cell-free therapy for acute kidney injury (AKI). However, the in vivo biodistribution of MSC …
[HTML][HTML] Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative …
S Dabrowska, A Andrzejewska, M Janowski… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …
Exosomes—beyond stem cells for restorative therapy in stroke and neurological injury
ZG Zhang, B Buller, M Chopp - Nature Reviews Neurology, 2019 - nature.com
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and
their families, but currently no drugs on the market promote neurological recovery. Limited …
their families, but currently no drugs on the market promote neurological recovery. Limited …
Isolation, cultivation, and characterization of human mesenchymal stem cells
D Mushahary, A Spittler, C Kasper, V Weber… - Cytometry Part …, 2018 - Wiley Online Library
Mesenchymal stem cells (MSC) exhibit a high self‐renewal capacity, multilineage
differentiation potential and immunomodulatory properties. This set of exceptional features …
differentiation potential and immunomodulatory properties. This set of exceptional features …
Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery
ML Merchant, IM Rood, JKJ Deegens… - Nature Reviews …, 2017 - nature.com
Urine is a valuable diagnostic medium and, with the discovery of urinary extracellular
vesicles, is viewed as a dynamic bioactive fluid. Extracellular vesicles are lipid-enclosed …
vesicles, is viewed as a dynamic bioactive fluid. Extracellular vesicles are lipid-enclosed …
Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …
cell types and participate in physiological and pathophysiological processes. EVs mediate …
[HTML][HTML] Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells repair critical-sized bone defects through enhanced …
X Qi, J Zhang, H Yuan, Z Xu, Q Li, X Niu… - … journal of biological …, 2016 - ncbi.nlm.nih.gov
Bone defects caused by trauma, severe infection, tumor resection and skeletal abnormalities
are common osteoporotic conditions and major challenges in orthopedic surgery, and there …
are common osteoporotic conditions and major challenges in orthopedic surgery, and there …