Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

DA Subramanian, R Langer, G Traverso - Journal of nanobiotechnology, 2022 - Springer
Oral delivery of therapeutics is the preferred route of administration due to ease of
administration which is associated with greater patient medication adherence. One major …

Mechanisms of nanoparticle transport across intestinal tissue: an oral delivery perspective

SA Ejazi, R Louisthelmy, K Maisel - ACS nano, 2023 - ACS Publications
Oral drug administration has been a popular choice due to patient compliance and limited
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …

Recent advances in oral and transdermal protein delivery systems

Y Yang, R Zhou, Y Wang, Y Zhang, J Yu… - Angewandte …, 2023 - Wiley Online Library
Protein and peptide drugs are predominantly administered by injection to achieve high
bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug …

Insulin-loaded liposomes packaged in alginate hydrogels promote the oral bioavailability of insulin

H Wu, J Nan, L Yang, HJ Park, J Li - Journal of Controlled Release, 2023 - Elsevier
Compared to subcutaneous injections, oral administration of insulin would be a preferred
route of drug administration for diabetic patients. For oral delivery, both liposomes and …

[HTML][HTML] pH-sensitive O-carboxymethyl chitosan/sodium alginate nanohydrogel for enhanced oral delivery of insulin

H Zhang, Z Gu, W Li, L Guo, L Wang, L Guo… - International Journal of …, 2022 - Elsevier
Oral drug delivery is considered the most preferred mode of treatment because of its high
patient compliance and minimal invasiveness. However, the oral delivery of protein drug has …

Progress and prospects of polysaccharide-based nanocarriers for oral delivery of proteins/peptides

H Yuan, C Guo, L Liu, L Zhao, Y Zhang, T Yin… - Carbohydrate …, 2023 - Elsevier
The oral route has long been recognized as the most preferred route for drug delivery as it
offers high patient compliance and requires minimal expertise. Unlike small molecule drugs …

Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy

YB Miao, T Xu, Y Gong, A Chen, L Zou, T Jiang… - Journal of …, 2023 - Springer
Oral administration is preferred over other drug delivery methods due to its safety, high
patient compliance, ease of ingestion without discomfort, and tolerance of a wide range of …

Self-assembled chitosan-insulin oral nanoparticles—A critical perspective review

MS Chellathurai, CL Yong, ZM Sofian… - International Journal of …, 2023 - Elsevier
Chitosan is an abundant natural cationic polysaccharide with excellent biodegradability,
bioadhesion, and biocompatibility. Chitosan is extensively researched for various particulate …

Advances in buccal and oral delivery of insulin

A Elsayed, M Al-Remawi, N Jaber… - International Journal of …, 2023 - Elsevier
Diabetes mellitus is a metabolic endocrine disease characterized by chronic hyperglycemia
with disturbances in metabolic processes, such as those related to carbohydrates, fat, and …

Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

C Chen, A Beloqui, Y Xu - Advanced drug delivery reviews, 2023 - Elsevier
Oral administration is the preferred route of administration based on the convenience for and
compliance of the patient. Oral nanomedicines have been developed to overcome the …