Diltiazem 1 is an orally and intravenously active calcium channel blocking agent shown to
be an effective and well-tolerated treatment for stable angina and angina due to coronary …

Background Many antihypertensive agents exist today for the treatment of primary
hypertension (systolic blood pressure≥ 140 mmHg or diastolic blood pressure≥ 90 mmHg …

Direct vasodilators and sympatholytic agents were some of the first antihypertensive
medications discovered and utilized in the past century. However, side effect profiles and the …

Hypertension is associated with increased cardio-and cerebrovascular morbidity and
mortality; antihypertensive drugs have been shown to reduce the risk of adverse cardio-and …

The major antihypertensive mechanism of calcium antagonists is by decreasing the systemic
vascular resistance, modified by the counter-regulatory responses of the baroreflexes and …

Background: The introduction of chronotherapy (that is improving a drugs therapeutic
efficacy by paralleling the drugs plasma levels to circadian rhythms) has recently become a …

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DURING THE PAST DECADE, many large cooperative studies and advisory bodies have
demonstrated and advocated the benefits of treating patients with mild to moderate …

Reserpine (Fig. 1), an alkaloid derived from the roots of certain species of Rauwolfia, was
isolated in 1952, and about 50 Rauwolfia alkaloids are known. Extracts of Rauwolfia, a plant …

Hypertension is associated with increased cardio and cerebrovascular morbidity and
mortality; antihypertensive drugs have been shown to reduce the risk of adverse cardio and …