Dynamic equilibrium between multiple active and inactive conformations explains regulation and oncogenic mutations in ErbB receptors
The ErbB growth factor receptor family members are key players in vital physiological and
pathological processes. Like other receptor tyrosine kinases, the ErbBs are bi-topic …
pathological processes. Like other receptor tyrosine kinases, the ErbBs are bi-topic …
The cytokinin oxidase/dehydrogenase CKX1 is a membrane-bound protein requiring homooligomerization in the endoplasmic reticulum for its cellular activity
MCE Niemann, H Weber, T Hluska, G Leonte… - Plant …, 2018 - academic.oup.com
Degradation of the plant hormone cytokinin is controlled by cytokinin oxidase/
dehydrogenase (CKX) enzymes. The molecular and cellular behavior of these proteins is …
dehydrogenase (CKX) enzymes. The molecular and cellular behavior of these proteins is …
Utility of FRET in studies of membrane protein oligomerization: The concept of the effective dissociation constant
DM McKenzie, D Wirth, TV Pogorelov, K Hristova - Biophysical journal, 2023 - cell.com
The activity of many membrane receptors is controlled through their lateral association into
dimers or higher-order oligomers. Although Förster resonance energy transfer (FRET) …
dimers or higher-order oligomers. Although Förster resonance energy transfer (FRET) …
Glycine dimerization motif in the N-terminal transmembrane domain of the high density lipoprotein receptor SR-BI required for normal receptor oligomerization and …
L Gaidukov, AR Nager, S Xu, M Penman… - Journal of Biological …, 2011 - ASBMB
Scavenger receptor class B, type I (SR-BI), a CD36 superfamily member, is an oligomeric
high density lipoprotein (HDL) receptor that mediates negatively cooperative HDL binding …
high density lipoprotein (HDL) receptor that mediates negatively cooperative HDL binding …
Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua
The transcriptional repressor Capicua (Cic) controls tissue patterning and restricts organ
growth, and has been recently implicated in several cancers. Cic has emerged as a primary …
growth, and has been recently implicated in several cancers. Cic has emerged as a primary …
Two GxxxG-like motifs facilitate promiscuous interactions of the human ErbB transmembrane domains
C Escher, F Cymer, D Schneider - Journal of molecular biology, 2009 - Elsevier
Members of the ErbB/HER family of epidermal growth factor receptor tyrosine kinases cross
a membrane with a single transmembrane (TM) helix. ErbB receptors form diverse homo …
a membrane with a single transmembrane (TM) helix. ErbB receptors form diverse homo …
Direct assessment of the effect of the Gly380Arg achondroplasia mutation on FGFR3 dimerization using quantitative imaging FRET
J Placone, K Hristova - 2012 - journals.plos.org
The Gly380Arg mutation in FGFR3 is the genetic cause for achondroplasia (ACH), the most
common form of human dwarfism. The mutation has been proposed to increase FGFR3 …
common form of human dwarfism. The mutation has been proposed to increase FGFR3 …
The physical basis behind achondroplasia, the most common form of human dwarfism
L He, K Hristova - Biophysical Journal, 2010 - cell.com
Fibroblast growth factor receptor 3 (FGFR3) is a receptor tyrosine kinase which plays an
important role in long bone development. The Gly380Arg mutation in FGFR3 …
important role in long bone development. The Gly380Arg mutation in FGFR3 …
[图书][B] The chemical biology of phosphorus
CT Walsh - 2020 - books.google.com
Alexander Todd, the 1957 Nobel laureate in chemistry is credited with the statement:" where
there is life, there is phosphorus". Phosphorus chemical biology underlies most of life's …
there is life, there is phosphorus". Phosphorus chemical biology underlies most of life's …
Computational insights into the potential of Withaferin-A, withanone and caffeic acid phenethyl ester for treatment of aberrant-EGFR driven lung cancers
The anticancer activities of Withaferin-A (Wi-A) and Withanone (Wi-N) from Ashwagandha
and Caffeic Acid Phenethyl Ester (CAPE) from honeybee propolis have been well …
and Caffeic Acid Phenethyl Ester (CAPE) from honeybee propolis have been well …