Primary mitochondrial disease and secondary mitochondrial dysfunction: importance of distinction for diagnosis and treatment
DM Niyazov, SG Kahler, RE Frye - Molecular syndromology, 2016 - karger.com
Mitochondrial disease refers to a heterogeneous group of disorders resulting in defective
cellular energy production due to abnormal oxidative phosphorylation (oxphos). Primary …
cellular energy production due to abnormal oxidative phosphorylation (oxphos). Primary …
The neurobiology of depression: an integrated overview from biological theories to clinical evidence
Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …
Mitochondrial potassium channels as druggable targets
A Wrzosek, B Augustynek, M Żochowska, A Szewczyk - Biomolecules, 2020 - mdpi.com
Mitochondrial potassium channels have been described as important factors in cell pro-life
and death phenomena. The activation of mitochondrial potassium channels, such as ATP …
and death phenomena. The activation of mitochondrial potassium channels, such as ATP …
[HTML][HTML] Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches
JF Hebert, L Myatt - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
Both obesity and gestational diabetes mellitus (GDM) lead to poor maternal and fetal
outcomes, including pregnancy complications, fetal growth issues, stillbirth, and …
outcomes, including pregnancy complications, fetal growth issues, stillbirth, and …
Mitochondria as pharmacological targets in Down syndrome
Mitochondria play a pivotal role in cellular energy-generating processes and are considered
master regulators of cell life and death fate. Mitochondrial function integrates signalling …
master regulators of cell life and death fate. Mitochondrial function integrates signalling …
Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage
K Sotolongo, J Ghiso, A Rostagno - Alzheimer's Research & Therapy, 2020 - Springer
Background Mounting evidence points to a crucial role of amyloid-β (Aβ) in the
pathophysiology of Alzheimer's disease (AD), a disorder in which brain glucose …
pathophysiology of Alzheimer's disease (AD), a disorder in which brain glucose …
Time to change: A systems pharmacology approach to disentangle mechanisms of drug-induced mitochondrial toxicity
CA Hoogstraten, JJ Lyon, JAM Smeitink… - Pharmacological …, 2023 - ASPET
An increasing number of commonly prescribed drugs are known to interfere with
mitochondrial function, which is associated with almost half of all Food and Drug …
mitochondrial function, which is associated with almost half of all Food and Drug …
Current challenges of mitochondrial potassium channel research
B Kulawiak, A Szewczyk - Frontiers in Physiology, 2022 - frontiersin.org
In this paper, the current challenges of mitochondrial potassium channels research were
critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria …
critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria …
[PDF][PDF] Focusing on the unfolded protein response and autophagy related pathways to reposition common approved drugs against COVID-19
S Nabirotchkin, AE Peluffo, J Bouaziz, D Cohen - 2020 - pdfs.semanticscholar.org
More than 179,000 individuals have fallen ill of the Coronavirus disease (COVID-19) caused
by the SARS-CoV-2 virus, which first emerged in China less than four months ago in …
by the SARS-CoV-2 virus, which first emerged in China less than four months ago in …
Status and prospect of novel treatment options toward alveolar and cystic echinococcosis
S Wang, Y Ma, W Wang, Y Dai, H Sun, J Li, S Wang… - Acta Tropica, 2022 - Elsevier
Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are the two most important
global parasitic infectious diseases caused by species of Echinococcus granulosus and E …
global parasitic infectious diseases caused by species of Echinococcus granulosus and E …