Primary mitochondrial disease and secondary mitochondrial dysfunction: importance of distinction for diagnosis and treatment

DM Niyazov, SG Kahler, RE Frye - Molecular syndromology, 2016 - karger.com
Mitochondrial disease refers to a heterogeneous group of disorders resulting in defective
cellular energy production due to abnormal oxidative phosphorylation (oxphos). Primary …

The neurobiology of depression: an integrated overview from biological theories to clinical evidence

F Ferrari, RF Villa - Molecular neurobiology, 2017 - Springer
Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …

Mitochondrial potassium channels as druggable targets

A Wrzosek, B Augustynek, M Żochowska, A Szewczyk - Biomolecules, 2020 - mdpi.com
Mitochondrial potassium channels have been described as important factors in cell pro-life
and death phenomena. The activation of mitochondrial potassium channels, such as ATP …

[HTML][HTML] Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches

JF Hebert, L Myatt - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
Both obesity and gestational diabetes mellitus (GDM) lead to poor maternal and fetal
outcomes, including pregnancy complications, fetal growth issues, stillbirth, and …

Mitochondria as pharmacological targets in Down syndrome

D Valenti, N Braidy, D De Rasmo, A Signorile… - Free Radical Biology …, 2018 - Elsevier
Mitochondria play a pivotal role in cellular energy-generating processes and are considered
master regulators of cell life and death fate. Mitochondrial function integrates signalling …

Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage

K Sotolongo, J Ghiso, A Rostagno - Alzheimer's Research & Therapy, 2020 - Springer
Background Mounting evidence points to a crucial role of amyloid-β (Aβ) in the
pathophysiology of Alzheimer's disease (AD), a disorder in which brain glucose …

Time to change: A systems pharmacology approach to disentangle mechanisms of drug-induced mitochondrial toxicity

CA Hoogstraten, JJ Lyon, JAM Smeitink… - Pharmacological …, 2023 - ASPET
An increasing number of commonly prescribed drugs are known to interfere with
mitochondrial function, which is associated with almost half of all Food and Drug …

Current challenges of mitochondrial potassium channel research

B Kulawiak, A Szewczyk - Frontiers in Physiology, 2022 - frontiersin.org
In this paper, the current challenges of mitochondrial potassium channels research were
critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria …

[PDF][PDF] Focusing on the unfolded protein response and autophagy related pathways to reposition common approved drugs against COVID-19

S Nabirotchkin, AE Peluffo, J Bouaziz, D Cohen - 2020 - pdfs.semanticscholar.org
More than 179,000 individuals have fallen ill of the Coronavirus disease (COVID-19) caused
by the SARS-CoV-2 virus, which first emerged in China less than four months ago in …

Status and prospect of novel treatment options toward alveolar and cystic echinococcosis

S Wang, Y Ma, W Wang, Y Dai, H Sun, J Li, S Wang… - Acta Tropica, 2022 - Elsevier
Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are the two most important
global parasitic infectious diseases caused by species of Echinococcus granulosus and E …