Oligonucleotides (oligos) have been under clinical development for approximately the past
30 years, beginning with antisense oligonucleotides (ASOs) and apatmers and followed …

Cancer is one of the leading causes of death worldwide. Conventional therapies, including
surgery, radiation, and chemotherapy have achieved increased survival rates for many types …

Hepatic veno-occlusive disease (VOD) or sinusoidal obstruction syndrome (SOS) is a rare
complication characterized by hepatomegaly, right-upper quadrant pain, jaundice, and …

It has been recently shown with clinical studies that COVID-19 pathogenesis is associated
with coagulopathy, however it differs from sepsis associated disseminated intravascular …

Hepatic veno‐occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially
life‐threatening complication of haematopoietic stem cell transplant (HSCT) conditioning …

PDRN is a proprietary and registered drug that possesses several activities: tissue repairing,
anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in …

The novel coronavirus disease (COVID-19) is associated with a high incidence of
coagulopathy and venous thromboembolism that may contribute to the worsening of the …

Objective Defibrotide is a heterogenous mixture of polyanionic oligonucleotides currently
approved for treatment of transplant‐associated venoocclusive disease. While defibrotide …

Vascular endothelial cells are major participants in and regulators of immune responses and
inflammation. Vascular endotheliitis is regarded as a host immune-inflammatory response of …

Abstract Veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS),
is a potentially life-threatening complication of hematopoietic stem cell transplantation …