Covalent inhibitors design and discovery
S De Cesco, J Kurian, C Dufresne… - European Journal of …, 2017 - Elsevier
In the history of therapeutics, covalent drugs occupy a very distinct category. While
representing a significant fraction of the drugs on the market, very few have been …
representing a significant fraction of the drugs on the market, very few have been …
[HTML][HTML] Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A
TT Chao, CY Wang, YL Chen, CC Lai, FY Chang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Afatinib has anti-tumor effect in non-small cell lung carcinoma (NSCLC) with epidermal
growth factor receptor (EGFR) mutation. We found afatinib can also induce apoptosis in …
growth factor receptor (EGFR) mutation. We found afatinib can also induce apoptosis in …
[HTML][HTML] Correlation between expression of epidermal growth factor receptor and adverse reactions after chemotherapy of advanced non-small-cell lung cancer
Z Hao, C Tian, F Yang, J Zhang - Pakistan Journal of Medical …, 2015 - ncbi.nlm.nih.gov
Objective: To analyze the correlation between expression of epidermal growth factor
receptor (EGFR) and adverse reactions after chemotherapy of advanced non-small-cell lung …
receptor (EGFR) and adverse reactions after chemotherapy of advanced non-small-cell lung …
Targeted therapy: genomic approaches
TN Beck, L Gabitova… - … Pharmacology and Drug …, 2018 - books.google.com
or entities specific to the pathology. Genomics has been a critical component of target
identification, and has greatly amplified the impact and potential of targeted therapy …
identification, and has greatly amplified the impact and potential of targeted therapy …
[PDF][PDF] Предимства при приложението на афатиниб като 1-ва и 2-ра линия на лечение за локално авансирал и метастатичен недребноклетъчен рак на белия …
T Zlatanova, J Arabadjiev, S Mustafa - pfigshare-u-files.s3.amazonaws.com
In the last 15 years, great progress has been made in the individualization of cancer therapy.
Non-small cell lung cancer (NSCLC) has been at the forefront of the precision oncology …
Non-small cell lung cancer (NSCLC) has been at the forefront of the precision oncology …
Targeted therapy for glioblastoma: Lessons learned and future directions
Glioblastoma is the most common adult malignant primary brain tumor, and carries a dismal
prognosis. After initial standard radiation therapy and chemotherapy with temozolomide, few …
prognosis. After initial standard radiation therapy and chemotherapy with temozolomide, few …