Review of pre-metastatic niches in lung metastasis: From cells to molecules, from mechanism to clinics
H Xie, Q Sun, X Chu, S Zhu, F Xie - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Distant metastasis is responsible for high mortality in most cancer cases and the lung is one
of the most common target organs, severely affecting the quality of daily life and overall …
of the most common target organs, severely affecting the quality of daily life and overall …
MDSCs in bone metastasis: mechanisms and therapeutic potential1
Z Li, Q Xia, Y He, L Li, P Yin - Cancer Letters, 2024 - Elsevier
Bone metastasis (BM) is a frequent complication associated with advanced cancer that
significantly increases patient mortality. Myeloid-derived suppressor cells (MDSCs) play a …
significantly increases patient mortality. Myeloid-derived suppressor cells (MDSCs) play a …
E3 ligase TRIM28 promotes anti-PD-1 resistance in non-small cell lung cancer by enhancing the recruitment of myeloid-derived suppressor cells
M Liang, Z Sun, X Chen, L Wang, H Wang… - Journal of Experimental …, 2023 - Springer
Background Alterations in several tripartite motif-containing (TRIM) family proteins have
been implicated in the pathogenesis of lung cancer. TRIM28, a member of the TRIM E3 …
been implicated in the pathogenesis of lung cancer. TRIM28, a member of the TRIM E3 …
Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers
A Georgievski, PS Bellaye, B Tournier… - Cell Death & …, 2024 - nature.com
We created valrubicin-loaded immunoliposomes (Val-ILs) using the antitumor prodrug
valrubicin, a hydrophobic analog of daunorubicin. Being lipophilic, valrubicin readily …
valrubicin, a hydrophobic analog of daunorubicin. Being lipophilic, valrubicin readily …
Single-cell analysis defines highly specific leukemia-induced neutrophils and links MMP8 expression to recruitment of tumor associated neutrophils during FGFR1 …
T Hu, B Cheng, A Matsunaga, T Zhang, X Lu… - … Hematology & Oncology, 2024 - Springer
Background Leukemias driven by activated, chimeric FGFR1 kinases typically progress to
AML which have poor prognosis. Mouse models of this syndrome allow detailed analysis of …
AML which have poor prognosis. Mouse models of this syndrome allow detailed analysis of …
Identifying the prognosis implication, immunotherapy response prediction value, and potential targeted compound inhibitors of integrin subunit α3 (ITGA3) in human …
J Gui, L Yang, J Liu, Y Li, M Zou, C Sun, L Huang… - Heliyon, 2024 - cell.com
The integrin subunit α3 (ITGA3) is a member of the integrin alpha chain protein family, which
could promote progression, metastasis, and invasion in some cancers. Still, its function in …
could promote progression, metastasis, and invasion in some cancers. Still, its function in …
Hallmarks of cancer resistance
M Tufail, JJ Hu, J Liang, CY He, WD Wan, YQ Huang… - Iscience, 2024 - cell.com
This review explores the hallmarks of cancer resistance, including drug efflux mediated by
ATP-binding cassette (ABC) transporters, metabolic reprogramming characterized by the …
ATP-binding cassette (ABC) transporters, metabolic reprogramming characterized by the …
Overnutrition and Lipotoxicity: Impaired Efferocytosis and Chronic Inflammation as Precursors to Multifaceted Disease Pathogenesis
V Mann, A Sundaresan, S Shishodia - Biology, 2024 - mdpi.com
Simple Summary Overnutrition, characterized by an excessive caloric intake, often leads to
lipotoxicity, a condition where lipids accumulate abnormally in non-adipose tissues. This …
lipotoxicity, a condition where lipids accumulate abnormally in non-adipose tissues. This …
The role of tumor-associated macrophages in tumor immune evasion
R Huang, T Kang, S Chen - Journal of Cancer Research and Clinical …, 2024 - Springer
Background Tumor growth is closely linked to the activities of various cells in the tumor
microenvironment (TME), particularly immune cells. During tumor progression, circulating …
microenvironment (TME), particularly immune cells. During tumor progression, circulating …
Clinical Trial on the Safety and Tolerability of Personalized Cancer Vaccines Using Human Platelet Lysate-Induced Antigen-Presenting Cells
T Koya, K Yoshida, M Togi, Y Niida, S Togi, H Ura… - Cancers, 2023 - mdpi.com
Simple Summary In this study, we developed human platelet lysate-induced antigen-
presenting cells (HPL-APCs) from peripheral monocytes with a high potency of presentation …
presenting cells (HPL-APCs) from peripheral monocytes with a high potency of presentation …