Multiple drug resistance (multidrug resistance; MDR), a phenomenon whereby human
tumours that acquire resistance to one type of therapy are found to be resistant to several …

Necrosis has long been described as a consequence of physico-chemical stress and thus
accidental and uncontrolled. Recently, it is becoming clear that necrotic cell death is as well …

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control,
promoting cell survival by interfering at an early stage in a cascade of events leading to …

Bcl-2 is a key apoptosis regulatory protein of the mitochondrial death pathway whose
function is dependent on its expression levels. Although Bcl-2 expression is controlled by …

Chronic lymphocytic leukaemia (CLL) is the most common B‐cell malignancy in the Western
world and exists as subtypes with very different clinical courses. CLL is generally described …

Introduction 3. Tea Polyphenols 4. Mechanisms of Action 4.1. Bcl-2 family members 4.2.
Matrix metalloproteinases 4.3. Ras/Map Kinases 4.4. PI3-kinase/AKT 4.5. Cyclooxygenases …

It is becoming increasingly clear that the proliferation of human tumours is driven by a small
proportion of cells, termed tumour stem cells, which have the properties of self-renewal. On …

The potent Myc oncoprotein plays a pivotal role as a regulator of tumorigenesis in numerous
human cancers of diverse origin. Experimental evidence shows that inhibiting Myc …

The decline in cognitive robustness with aging can be attributed to complex genetic
pathways involving many cellular dysfunctions, cumulative over time, precipitating in frailty …

Hydrogen peroxide is a key mediator of oxidative stress known to be important in various
cellular processes, including apoptosis. B-cell lymphoma-2 (Bcl-2) is an oxidative stress …