Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

The functional roles of the circRNA/Wnt axis in cancer

C Xue, G Li, Q Zheng, X Gu, Z Bao, J Lu, L Li - Molecular Cancer, 2022 - Springer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

[HTML][HTML] Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling

M Entezari, M Ghanbarirad, A Taheriazam… - Biomedicine & …, 2022 - Elsevier
Among the different kinds of tumors threatening human life, lung cancer is one that is
commonly observed in both males and females. The aggressive behavior of lung cancer …

Association of the epithelial–mesenchymal transition (EMT) with cisplatin resistance

M Ashrafizadeh, A Zarrabi, K Hushmandi… - International journal of …, 2020 - mdpi.com
Therapy resistance is a characteristic of cancer cells that significantly reduces the
effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent …

[HTML][HTML] The metastasizing mechanisms of lung cancer: recent advances and therapeutic challenges

S Xie, Z Wu, Y Qi, B Wu, X Zhu - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Lung cancer is one of the common malignant tumors that threaten human life with serious
incidence and high mortality. According to the histopathological characteristics, lung cancer …

LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer

Y Zhang, X Dong, X Guo, C Li, Y Fan, P Liu, D Yuan… - Molecular cancer, 2023 - Springer
Background Breast cancer is the most common malignant tumor that threatens women's
health. Attention has been paid on the study of long-non-coding RNA (lncRNA) in breast …

MiRNAs and cancer: key link in diagnosis and therapy

Y Shi, Z Liu, Q Lin, Q Luo, Y Cen, J Li, X Fang, C Gong - Genes, 2021 - mdpi.com
Since the discovery of the first microRNA (miRNA), the exploration of miRNA biology has
come to a new era in recent decades. Monumental studies have proven that miRNAs can be …

Tumor metastasis: Mechanistic insights and therapeutic interventions

M Liu, J Yang, B Xu, X Zhang - MedComm, 2021 - Wiley Online Library
Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers

Y Zhang, Q Mao, Q Xia, J Cheng, Z Huang, Y Li… - Journal of hematology & …, 2021 - Springer
Altered metabolic patterns in tumor cells not only meet their own growth requirements but
also shape an immunosuppressive microenvironment through multiple mechanisms …

Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications

H Khanbabaei, S Ebrahimi… - Journal of Experimental …, 2022 - Springer
Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic
development during which epithelial cells acquire mesenchymal characteristics, and the …