The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …

Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we
age. Heart function gradually declines in old age, leading to continuous heart failure, even in …

Induced pluripotent stem cells (iPSCs) have become a prevalent topic after their discovery,
advertised as an ethical alternative to embryonic stem cells (ESCs). Due to their ability to …

Various groups including animal protection organizations, medical organizations, research
centers, and even federal agencies such as the US Food and Drug Administration, are …

Stroke is an important disease with unmet clinical need. To uncover novel paths for
treatment, it is of critical importance to develop relevant laboratory models that may help to …

Functional changes to cardiomyocytes are undesirable during drug discovery and
identifying the inotropic effects of compounds is hence necessary to decrease the risk of …

Background: We hypothesize that the poor survival outcomes of end-stage kidney disease
(ESKD) patients undergoing hemodialysis are associated with a low filtering efficiency and …

Dogs are the experimental model in many types of biomedical research. Each year,
hundreds of publications report the use of dogs in invasive biomedical procedures, often …

Impact ionization of high-velocity cosmic dust particles has been used as a basic principle
for dust detectors in space for many decades. It has provided optimum means to gain insight …

Hydrogel microfibers are hydrogel materials engineered into fiber structures. Techniques
such as wet spinning, microfluidic spinning, and 3D bioprinting are often used to prepare …