Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons
in the central nervous system (CNS), but the structural diversity of their polysaccharides has …

Although the local environment is known to regulate neural stem cell (NSC) maintenance in
the central nervous system, little is known about the molecular identity of the signals …

The extracellular matrix (ECM) of the brain plays crucial roles during the development,
maturation, and regeneration of the CNS. In a subpopulation of neurons, the ECM …

CNS damage often results in demyelination of spared axons due to oligodendroglial cell
death and dysfunction near the injury site. Although new oligodendroglia are generated …

J. Neurochem.(2011) 119, 176–188. Abstract The formation of the glial scar following a
spinal cord injury presents a significant barrier to the regenerative process. It is primarily …

The extracellular matrix (ECM) plays diverse roles in several physiological and pathological
conditions. In the brain, the ECM is unique both in its composition and in functions …

Proteoglycans (PGs) are a diverse family of proteins that consist of one or more
glycosaminoglycan (GAG) chains, covalently linked to a core protein. PGs are major …

Central nervous system (CNS) injuries are particularly traumatic, owing to the limited
capabilities of the mammalian CNS for repair. Nevertheless, functional recovery is observed …

Robust axonal growth is required during development to establish neuronal connectivity.
However, stable fibre patterns are necessary to maintain adult mammalian central nervous …

Aged individuals exhibit reduced functional recovery after stroke. We examined the
expression profile in aged animals of a recently identified group of growth-associated genes …