Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care
due to their excellent safety profiles and their activity against a wide spectrum of pathogens …

Due to complex maturational and physiological changes that characterize neonates and
affect their response to pharmacological treatments, neonatal pharmacology is different from …

Antimicrobial resistance is considered one of the major threats to public health and is an
important factor that influences the patient's outcome in the intensive care unit …

Aminoglycosides are broad-spectrum antibiotics largely used in children, but they have
potential toxic side effects, including ototoxicity. Ototoxicity from aminoglycosides is …

Children show a very wide range of physical development processes. These changes
impact pharmacokinetic (PK) variability in pediatric patients. Most PK studies have been …

Vancomycin is a glycopeptide antibiotic that has been adopted in clinical practice to treat
gram-positive infections for more than 70 years. Despite vancomycin's long history of …

Age-appropriateness of a formulation is the ability to deliver variable but accurate doses to
the paediatric population in a safe and acceptable manner to improve medical adherence …

Objectives Cefepime is an antibiotic commonly used to treat sepsis and is cleared by renal
excretion. Cefepime dosing requires adjustment in patients with decreased kidney function …

Abstract Background and Objective Voriconazole pharmacokinetics are highly variable in
pediatric patients, and the optimal dosage has yet to be determined. The purpose of this …

Neonates face heightened susceptibility to drug toxicity, often exposed to off-label
medications with dosages extrapolated from adult or pediatric studies. Premature infants in …