Purpose Adequate dosing of antimicrobials is critical to properly treat infections and limit
development of resistance and adverse effects. Limited guidance exist for antimicrobial …

Abstract Background and Objective Voriconazole pharmacokinetics are highly variable in
pediatric patients, and the optimal dosage has yet to be determined. The purpose of this …

Abstract Introduction Adverse drug reactions (ADRs) to anti-infectives affect especially
hospitalized children and contribute to increased morbidity, mortality, length of stay, and …

Abstract Knowledge of infectious diseases and their treatments is constantly evolving. New
infectious agents are regularly discovered, mainly due to improvement of identification …

Vancomycin is a glycopeptide antibiotic used for prophylaxis and treatment of infections
caused by methicillin-resistant Staphylococcus aureus. Although major organ sizes and …

Résumé Depuis près d'un demi-siècle, de nombreuses études ont démontré la valeur des
paramètres pharmacocinétiques/pharmacodynamiques (PK/PD) sériques pour prédire …

Molecular Pharmacology studies pharmacology at the molecular level. Understanding the
molecular mechanisms behind drug action is one of the most crucial areas of molecular …

Background: Trillions of microbial cells in the human body are thought to be vital to human
survival. Microbial cell populations are at maximum density within the intestinal …

Premature infants with neonatal sepsis often require antibiotics, such as Gentamicin,
commonly used in the NICU to treat suspected Gram-negative infections associated with …

Many drugs or their metabolites are eliminated from the body by the kidneys. Renal function
is an important covariate to describe variability in drug clearance (CL) of renally eliminated …