Two-thirds of all human conceptions are lost, in most cases before clinical detection. The
lack of detailed understanding of the causes of pregnancy losses constrains focused …

Purpose Existing resources that characterize the essentiality status of genes are based on
either proliferation assessment in human cell lines, viability evaluation in mouse knockouts …

Stillbirth, defined as fetal death at 20 weeks gestation or later, is a devastating pregnancy
outcome affecting 1 in 175 pregnancies in the United States. Although efforts to understand …

Monogenic disease are often understood as being either recessive, when one pathogenic
variant is asymptomatic and two variants are required for symptomatic disease, or dominant …

Abstract Objectives In the West Midlands Regional Genetic Service, cases of perinatal death
with a possible genetic diagnosis are evaluated by the Perinatal Pathology Genetic …

Background: The fetal monogenic causes of early pregnancy losses (EPLs) are mainly
unknown, with only a few articles on the subject published. In our previous study of EPLs …

Factoring genetics in the management of implantation and early pregnancy - Focus on
Reproduction - ESHRE Become a member Log In Search for: Contact Us Member Only Content …