Targeting vascular calcification in chronic kidney disease

AJ Nelson, P Raggi, M Wolf, AM Gold… - Basic to Translational …, 2020 - jacc.org
Cardiovascular (CV) disease remains an important cause of morbidity and mortality for
patients with chronic kidney disease (CKD). Although clustering of traditional risk factors with …

End-stage renal disease, inflammation and cardiovascular outcomes

L Dai, E Golembiewska, B Lindholm… - Expanded …, 2017 - karger.com
Despite marked improvements in renal replacement therapy during the last 30 years, the
age-adjusted mortality rate in end-stage renal disease (ESRD) patients is still unacceptably …

Circulating endotoxemia: a novel factor in systemic inflammation and cardiovascular disease in chronic kidney disease

CW McIntyre, LEA Harrison, MT Eldehni… - Clinical Journal of the …, 2011 - journals.lww.com
Results Circulating endotoxemia was most notable in those with the highest CV disease
burden (increasing with CKD stage), and a sharp increase was observed after initiation of …

[HTML][HTML] Fibroblast growth factor 23 is not associated with and does not induce arterial calcification

JJ Scialla, WL Lau, MP Reilly, T Isakova, HY Yang… - Kidney international, 2013 - Elsevier
Elevated fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease in
patients with chronic kidney disease. As a potential mediating mechanism, FGF23 induces …

Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?

P Stenvinkel, J Jesu, J Axelsson… - Clinical journal of the …, 2008 - journals.lww.com
Premature cardiovascular disease (CVD), including stroke, peripheral vascular disease,
sudden death, coronary artery disease, and congestive heart failure, is a notorious problem …

Hemodialysis-induced repetitive myocardial injury results in global and segmental reduction in systolic cardiac function

JO Burton, HJ Jefferies, NM Selby… - Clinical Journal of the …, 2009 - journals.lww.com
Background and objectives: Hemodialysis (HD)-induced regional wall motion abnormalities
(RWMAs) are common in HD patients and driven by ischemia. In nondialysis patients …

Progressive vascular calcification over 2 years is associated with arterial stiffening and increased mortality in patients with stages 4 and 5 chronic kidney disease

MK Sigrist, MW Taal, P Bungay… - Clinical Journal of the …, 2007 - journals.lww.com
Background and objectives: Vascular calcification is increasingly recognized as an
important component of cardiovascular disease in chronic kidney disease. The objective of …

Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients

MM Nasrallah, AR El-Shehaby… - Nephrology Dialysis …, 2010 - academic.oup.com
Background. Vascular calcification has detrimental consequences on chronic kidney
disease (CKD) patients, yet its pathogenesis is not fully understood. Fibroblast growth factor …

Calcification in atherosclerosis

N Alexopoulos, P Raggi - Nature Reviews Cardiology, 2009 - nature.com
Coronary calcification has long been known to occur as a part of the atherosclerotic process,
although whether it is a marker of plaque stability or instability is still a topic of considerable …

Associations between vascular calcification, arterial stiffness and bone mineral density in chronic kidney disease

ND Toussaint, KK Lau, BJ Strauss… - Nephrology Dialysis …, 2008 - academic.oup.com
Background. Vascular calcification (VC) and arterial stiffness are major contributors to
cardiovascular (CV) disease in chronic kidney disease (CKD). Both are independent …