The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes
ER stress and induces the unfolded protein response (UPR) and other mechanisms to …

In 2013, two seminal studies identified gain-of-function mutations in the Calreticulin (CALR)
gene in a subset of JAK2/MPL-negative myeloproliferative neoplasm (MPN) patients. CALR …

Background Diabetic nephropathy (DN) is an increasing threat to human health and
regarded to be the leading cause of end-stage renal disease worldwide. Exosomes delivery …

Myeloproliferative neoplasms (MPNs) are clonal disorders originated by the serial
acquisition of somatic mutations in hematopoietic stem/progenitor cells. The major clinical …

Mutations in JAK2, myeloproliferative leukemia virus (MPL), or calreticulin (CALR) occur in
hematopoietic stem cells (HSCs) and are detected in more than 80% of patients with …

Disease progression of myeloproliferative neoplasms is the result of increased genomic
complexity. Since the ability to predict disease evolution is crucial for clinical decisions, we …

Novel therapeutics are urgently needed to prevent opportunistic infections in
immunocompromised individuals undergoing cancer treatments or other immune …

Calreticulin (CALR) is a chaperone present in the endoplasmic reticulum, which is involved
in the quality control of N-glycosylated proteins and storage of calcium ions. In 2013, the C …

Calreticulin is recognized as a multifunctional protein that serves an essential role in diverse
biological processes that include wound healing, modification and folding of proteins …

Novel therapeutics are urgently needed to prevent opportunistic infections in
immunocompromised individuals undergoing cancer treatments or other immune …