Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as
host factors in infectious diseases. In particular, they were implicated in the pathogenesis of …

Simple Summary Novel therapeutic targets are needed to improve treatments of aggressive
cancers and viral diseases. Tetraspanins represent an emerging class of anticancer targets …

Metal ions are essential elements present in biological systems able to facilitate many
cellular processes including proliferation, signaling, DNA synthesis and repair. Zinc ion (Zn …

A case of a young girl diagnosed with an antibody deficiency syndrome serves to highlight
the role of CD81 in B cell biology. Moreover, this case illustrates a fundamental function of …

The presence of Zn 2+ at protein–protein interfaces modulates complex function, stability,
and introduces structural flexibility/complexity, chemical selectivity, and reversibility driven in …

The tetraspanins constitute a conserved superfamily of four-span membrane proteins that
are widely distributed in multi-cellular organisms. A characteristic property of tetraspanins is …

Despite the great research effort placed during the last decades in HIV-1 study, still some
aspects of its replication cycle remain unknown. All this powerful research has succeeded in …

HIV-1 contact with target cells triggers F-actin rearrangements that are essential for several
steps of the viral cycle. Successful HIV entry into CD4+ T cells requires actin reorganization …

CD4 interactions with class II major histocompatibility complex (MHC) molecules are
essential for CD4+ T cell development, activation, and effector functions. While its …

HIV-1 infection enhances HCV replication and as a consequence accelerates HCV-
mediated hepatocellular carcinoma (HCC). However, the precise molecular mechanism by …