Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults
such as injury, surgery and infection. Excessive extracellular matrix and adhesions contract …

Despite the substantial gains in our understanding of NAFLD/NASH over the past 2
decades, there has been some dissatisfaction with the terminology “non‐alcoholic” which …

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Recent studies have
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …

Coronary artery disease (CAD) is the leading cause of death worldwide. Oxidative stress
and inflammation are major mechanisms responsible for the progression of CAD. Nuclear …

Backgrounds and Aims Activation of hepatic stellate cells (HSCs) is a central driver of
fibrosis. This study aimed to elucidate the role of the deacetylase sirtuin 6 (Sirt6) in HSC …

Idiopathic pulmonary fibrosis (IPF) is a worldwide disease characterized by the chronic and
irreversible decline of lung function. Currently, there is no drug to successfully treat the …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Idiopathic pulmonary fibrosis (IPF) is a debilitating condition where excess collagen
deposition occurs in the extracellular matrix. At first sight, it is expected that the level of …

Ferroptosis is a new form of regulated cell death. Fibroblast-to-myofibroblast differentiation is
known to be involved in the pathogenesis of idiopathic pulmonary fibrosis. Utilizing HFL1 …