Bioactive peptides are a group of biological molecules that are normally buried in the
structure of parent proteins and become active after the cleavage of the proteins. Another …

In general, heterocyclic compounds are a significant source of pharmacologically active
compounds. Among them, the indole scaffold widely distributes in natural products and …

The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

Histone deacetylase (HDAC) inhibitors are an emerging class of therapeutics with potential
as anticancer drugs. The rationale for developing HDAC inhibitors (and other chromatin …

Background HDAC6, a structurally and functionally distinct member of the HDAC family, is
an integral part of multiple cellular functions such as cell proliferation, apoptosis …

Maintaining the structure of protein and peptide drugs has become one of the most important
goals of scientists in recent decades. Cold and thermal denaturation conditions …

This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

Lysine acetylation is a reversible modification controlled by two groups of enzymes: lysine
acetyltransferases (KATs) and lysine deacetylases (KDACs). Acetylated lysine residues are …

Although continuous researches are going on for the discovery of new chemotherapeutic
agents, resistance to these anticancer agents has made it really difficult to reach the fruitful …