Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

Rho-associated coiled-coil-containing kinases (ROCKs), serine/threonine protein kinases,
were initially identified as downstream targets of the small GTP-binding protein Rho …

Pulmonary hypertension (PH) is a cardiovascular disease caused by extensive vascular
remodeling in the lungs, which ultimately leads to death in consequence of right ventricle …

Heart disease and cancer are two major causes of morbidity and mortality in the
industrialized countries, and their increasingly recognized connections are shifting the focus …

Introduction Fibrosis is a disease that damages organs and even causes death. Because of
the complicated pathogenesis, the development of drugs for fibrosis is challenging. In the …

Background Intestinal obstruction caused by intestinal fibrosis is a common and serious
complication of Crohn's disease (CD). Intestinal fibroblasts, the main effector cells mediating …

Fibrosis is an outcome of tissue repair after different types of injuries. The homeostasis of
extracellular matrix is broken, and excessive deposition occurs, affecting the normal function …

Glaucoma is a chronic and progressive neurodegenerative disease characterized by the
loss of retinal ganglion cells and visual field defects, currently affecting around 1% of the …

Patients with heart failure with preserved ejection fraction (HFpEF) and atherosclerosis-
driven coronary artery disease (CAD) will have ongoing fibrotic remodeling both in the …

The correlation between long-QT and connexin 43 (Cx43) status and localization in elderly
rats was determined to demonstrate a correlation between insulin resistance (IR), ischemia …