Background: Risk of severe COVID-19 increases with age, is greater in males, and is
associated with lymphopenia, but not with higher burden of SARS-CoV-2. It is unknown …

The bladder is continuously protected by passive defences such as a mucus layer,
antimicrobial peptides and secretory immunoglobulins; however, these defences are …

Innate lymphoid cells (ILCs) represent a distinct branch of the lymphoid lineage composed
of 3 major subpopulations: ILC1, ILC2, and ILC3. ILCs are mainly described as tissue …

The survival of helminths in the host over long periods of time is the result of a process of
adaptation or dynamic co-evolution between the host and the parasite. However, infection …

T‐bet and Eomes are T‐box transcription factors that drive the differentiation and function of
cytotoxic lymphocytes such as NK cells. Their DNA‐binding domains are highly similar …

Decades after the discovery of natural killer (NK) cells, their developmental pathways in
mice and humans have not yet been completely deciphered. Accumulating evidence …

Current approaches to prevent and treat graft-versus-host disease (GVHD) after stem cell
transplantation rely principally on pharmacological immune suppression. Such approaches …

Neuronal signals have emerged as pivotal regulators of group 2 innate lymphoid cells
(ILC2s) that regulate tissue homeostasis and allergic inflammation. The molecular pathways …

Innate sensing of pathogens by pattern-recognition receptors (PRRs) plays essential roles in
the innate discrimination between self and non-self components, leading to the generation …

Despite the importance of Th17 cells in autoimmune diseases, it remains unclear how they
control other inflammatory cells in autoimmune tissue damage. Using a model of …