Precision positioning systems with large working stroke (millimeter or more) and micro/nano-
scale positioning resolution are widely required in both scientific research and industries …

Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

Forces generated by protein polymerization are important for various forms of cellular
motility. Assembling microtubules, for instance, are believed to exert pushing forces on …

Single-molecule observation and manipulation have come of age. With the advent of optical
tweezers and other methods for probing and imaging single molecules, investigators have …

Molecular motors are protein machines whose directed movement along cytoskeletal
filaments is driven by ATP hydrolysis. Eukaryotic cells contain motors that help to transport …

This book provides the reader with an account of some of the experimental evidence on
which our present knowledge is based. The third edition of this highly successful book has …

The spatial distribution of intermolecular forces governs macromolecular interactions. The
atomic force microscope, a relatively new tool for investigating interaction forces between …

A simple imaging method for direct determination of single-molecule orientations is
presented that uses a wide-field epifluorescence microscope and a sensitive CCD camera …

Chemomechanical transduction was studied in single fibers isolated from human skeletal
muscle containing different myosin isoforms. Permeabilized fibers were activated by laser …

Actomyosin, a complex of actin filaments and myosin motor proteins, is responsible for force
generation during muscle contraction. To resolve the individual mechanical events of force …