Sex differences in cancer driver genes and biomarkers
Cancer differs significantly between men and women; even after adjusting for known
epidemiologic risk factors, the sexes differ in incidence, outcome, and response to therapy …
epidemiologic risk factors, the sexes differ in incidence, outcome, and response to therapy …
A novel mechanism driving poor-prognosis prostate cancer: overexpression of the DNA repair gene, ribonucleotide reductase small subunit M2 (RRM2)
YZ Mazzu, J Armenia, G Chakraborty, Y Yoshikawa… - Clinical Cancer …, 2019 - AACR
Purpose: Defects in genes in the DNA repair pathways significantly contribute to prostate
cancer progression. We hypothesize that overexpression of DNA repair genes may also …
cancer progression. We hypothesize that overexpression of DNA repair genes may also …
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors
C Kaittanis, C Andreou, H Hieronymus, N Mao… - Journal of experimental …, 2018 - rupress.org
Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly
expressed on prostate cancer. Its expression correlates inversely with survival and …
expressed on prostate cancer. Its expression correlates inversely with survival and …
Aneuploidy drives lethal progression in prostate cancer
KH Stopsack, CA Whittaker, TA Gerke… - Proceedings of the …, 2019 - National Acad Sciences
Aneuploidy, defined as chromosome gains and losses, is a hallmark of cancer. However,
compared with other tumor types, extensive aneuploidy is relatively rare in prostate cancer …
compared with other tumor types, extensive aneuploidy is relatively rare in prostate cancer …
Development and validation of a 28-gene hypoxia-related prognostic signature for localized prostate cancer
Background Hypoxia is associated with a poor prognosis in prostate cancer. This work
aimed to derive and validate a hypoxia-related mRNA signature for localized prostate …
aimed to derive and validate a hypoxia-related mRNA signature for localized prostate …
Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression
G Chakraborty, J Armenia, YZ Mazzu… - Clinical Cancer …, 2020 - AACR
Purpose: Previous sequencing studies revealed that alterations of genes associated with
DNA damage response (DDR) are enriched in men with metastatic castration-resistant …
DNA damage response (DDR) are enriched in men with metastatic castration-resistant …
Genomic predictors of outcome in prostate cancer
Context Given the highly variable behavior and clinical course of prostate cancer (PCa) and
the multiple available treatment options, a personalized approach to oncologic risk …
the multiple available treatment options, a personalized approach to oncologic risk …
SPOP mutation leads to genomic instability in prostate cancer
G Boysen, CE Barbieri, D Prandi, M Blattner, SS Chae… - Elife, 2015 - elifesciences.org
Genomic instability is a fundamental feature of human cancer often resulting from impaired
genome maintenance. In prostate cancer, structural genomic rearrangements are a common …
genome maintenance. In prostate cancer, structural genomic rearrangements are a common …
Integrative epigenetic taxonomy of primary prostate cancer
Abstract The Androgen Receptor (AR) is the key-driving transcription factor in prostate
cancer, tightly controlled by epigenetic regulation. To date, most epigenetic profiling has …
cancer, tightly controlled by epigenetic regulation. To date, most epigenetic profiling has …
Pan-cancer analysis of CDK12 alterations identifies a subset of prostate cancers with distinct genomic and clinical characteristics
Background CDK12 genomic alterations occur in several tumor types, but little is known
about their oncogenic role and clinical significance. Objective To describe the landscape of …
about their oncogenic role and clinical significance. Objective To describe the landscape of …