[HTML][HTML] Copy number signature analysis tool and its application in prostate cancer reveals distinct mutational processes and clinical outcomes
Genome alteration signatures reflect recurring patterns caused by distinct endogenous or
exogenous mutational events during the evolution of cancer. Signatures of single base …
exogenous mutational events during the evolution of cancer. Signatures of single base …
[HTML][HTML] Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis
YY Chen, JY Ge, SY Zhu, ZM Shao, KD Yu - Nature communications, 2022 - nature.com
Copy number alterations (CNAs) are pivotal genetic events in triple-negative breast cancer
(TNBC). Here, our integrated copy number and transcriptome analysis of 302 TNBC patients …
(TNBC). Here, our integrated copy number and transcriptome analysis of 302 TNBC patients …
[HTML][HTML] Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations
Background Invasive cribriform and intraductal carcinoma (CR/IDC) is associated with
adverse outcome of prostate cancer patients. The aim of this study was to determine the …
adverse outcome of prostate cancer patients. The aim of this study was to determine the …
Chromosomal instability in tumor initiation and development
DH Bach, W Zhang, AK Sood - Cancer research, 2019 - AACR
Chromosomal instability (CIN) is one of the major forms of genomic instability in various
human cancers and is recognized as a common hallmark of tumorigenesis and …
human cancers and is recognized as a common hallmark of tumorigenesis and …
[HTML][HTML] APOBEC mutagenesis and copy-number alterations are drivers of proteogenomic tumor evolution and heterogeneity in metastatic thoracic tumors
Intratumor mutational heterogeneity has been documented in primary non-small-cell lung
cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic …
cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic …
Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer
GK Hubbard, LN Mutton, M Khalili, RP McMullin… - Cancer research, 2016 - AACR
Genetic instability, a hallmark feature of human cancers including prostatic
adenocarcinomas, is considered a driver of metastasis. Somatic copy number alterations …
adenocarcinomas, is considered a driver of metastasis. Somatic copy number alterations …
Molecular subtypes of prostate cancer
K Arora, CE Barbieri - Current Oncology Reports, 2018 - Springer
Abstract Purpose of Review This review will examine the taxonomy of PCa subclasses
across disease states, explore the relationship among specific alterations, and highlight …
across disease states, explore the relationship among specific alterations, and highlight …
Low-pass whole-genome sequencing of circulating cell-free DNA demonstrates dynamic changes in genomic copy number in a squamous lung cancer clinical cohort
X Chen, CW Chang, JM Spoerke, KE Yoh… - Clinical Cancer …, 2019 - AACR
Purpose: We developed a method to monitor copy number variations (CNV) in plasma cell-
free DNA (cfDNA) from patients with metastatic squamous non–small cell lung cancer …
free DNA (cfDNA) from patients with metastatic squamous non–small cell lung cancer …
Prognostic value of low-pass whole genome sequencing of circulating tumor DNA in metastatic castration-resistant prostate cancer
Background Multiple treatments are available for metastatic castration-resistant prostate
cancer (mCRPC), including androgen receptor signaling inhibitors (ARSI) enzalutamide and …
cancer (mCRPC), including androgen receptor signaling inhibitors (ARSI) enzalutamide and …
Advances in circulating tumor DNA analysis
The analysis of cell-free circulating tumor DNA (ctDNA) is a very promising tool and might
revolutionize cancer care with respect to early detection, identification of minimal residual …
revolutionize cancer care with respect to early detection, identification of minimal residual …