Abstract Nuclear Factor Kappa-Β (NF-kB) is recognized as one of the main inflammatory
pathways in the Autoimmune Disease (AD) Rheumatoid Arthritis (RA), which exhibits high …

Chemokines are pivotal players in instigation and perpetuation of synovitis through
leukocytes egress from the blood circulation into the inflamed articulation. Multitudinous …

Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by
uncontrolled joint inflammation and destruction of bone and cartilage. We previously …

In chronic infectious diseases caused by gram-negative bacteria, such as osteomyelitis,
septic arthritis, and periodontitis, osteoclastic activity is enhanced with elevated …

Background We have recently analyzed the profile of T-cell subtypes based on chemokine
receptor expression in blood from untreated early rheumatoid arthritis (ueRA) patients …

Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint damage and
even disability. Although there are various clinical therapies for RA, some patients still have …

There are several chemokines and their receptors involved in the pathogenesis of chronic
inflammatory arthritis. Of those, CXCL10 and its receptor, CXCR3, are increased in many …

Previous reports have shown that osteoblasts are mechano-sensitive. Low-intensity pulsed
ultrasound (LIPUS) induces osteoblast differentiation and is an established therapy for bone …

Osteoarthritis (OA) in obese individuals is often attributed to joint loading. However, a
subtype of OA, Metabolic OA, may be due to obesity-related intrinsic factors but remains to …

Background The efficacy of B cell-depleting therapies for rheumatoid arthritis underscores
antibody-independent functions of effector B cells such as cognate T–B interactions and …