Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

Although recent genome-wide studies have provided valuable insights into the genetic basis
of human disease, they have explained relatively little of the heritability of most complex …

At fertilization, the gametes endow the embryo with a genomic blueprint, the integrity of
which is affected by the age and environmental exposures of both parents. Recent studies …

Biology presents many wonders, but one of the most remarkable is how a complex
multicellular organism grows from a single cell. Until recently, the processes involved …

Proteins do not function in isolation; it is their interactions with one another and also with
other molecules (eg DNA, RNA) that mediate metabolic and signaling pathways, cellular …

Much attention has been given to the idea of transgenerational epigenetic inheritance, but
fundamental questions remain regarding how much takes place and the impact that this …

It appears that the genetic programming of humans and other complex organisms has been
misunderstood for the past 50 years, due to the assumption that most genetic information is …

In recent years, striking new evidence has demonstrated non-genetic inheritance of
acquired traits associated with parental environmental exposures. In particular, this …

Neo-Darwinian evolutionary theory is based on exquisite selection of phenotypes caused by
small genetic variations, which is the basis of quantitative trait contribution to phenotype and …

Environmental epigenetics has an important role in regulating phenotype formation or
disease etiology. The ability of environmental factors and exposures early in life to alter …