Anatomically modern humans overlapped and mated with Neandertals such that non-
African humans inherit~ 1 to 3% of their genomes from Neandertal ancestors. We identified …

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have
met with limited success. We sought to increase statistical power to detect disease loci by …

Although genome-wide association studies have successfully identified thousands of risk
loci for complex traits, only a handful of the biologically causal variants, responsible for …

Background Gene set enrichment (GSE) analysis is a popular framework for condensing
information from gene expression profiles into a pathway or signature summary. The …

Modern genetic data combined with appropriate statistical methods have the potential to
contribute substantially to our understanding of human history. We have developed an …

Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of
unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in …

Segments of indentity-by-descent (IBD) detected from high-density genetic data are useful
for many applications, including long-range phase determination, phasing family data …

Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to
various agro-climatic conditions is important to world food security. Here we have …

mRNA translation and decay appear often intimately linked although the rules of this
interplay are poorly understood. In this study, we combined our recent P-body transcriptome …

In a pair of seminal papers, Sewall Wright and Gustave Malécot introduced F ST as a
measure of structure in natural populations. In the decades that followed, a number of …