Alkaloids are plant secondary metabolite. They are well known nitrogen-containing natural
bioactive compounds. Cutting edge research is going on alkaloids to unravel novel …

Background Cancer is the most common cause of death and is still a serious public health
problem. Alkaloids, a class of bioactive compounds widely diffused in plants, especially …

Boldine is an alkaloid obtained from the medicinal herb Peumus boldus (Mol.)(Chilean
boldo tree; boldo) and belongs to the family Monimiaceae. It exhibits a wide range of …

Natural nitrogen heterocycles biotransformation has been extensively used to prepare
synthetic drugs and explore the fate of therapeutic agents inside the body. Herein, the ability …

The alkaloid boldine occurs in the Chilean boldo tree (Peumus boldus). It acts as a free
radical scavenger and controls glycemia in diabetic rats. Various mechanisms have been …

Boldo leaves (Boldo folium, from Peumus boldus Mol.) are very frequently used as a
medicinal herb in Chile and are exported to many countries to be used in teas or as extracts …

Objective Boldine is a plant-derived bioactive compound that has a beneficial impact on
human health. Boldine is an aporphine alkaloid mainly obtained from the leaves and bark of …

Boldine, the major alkaloid from the Chilean Boldo tree, is used in traditional medicine to
support bile production, but evidence to support this function is controversial. We analyzed …

Methotrexate (MTX) is an antineoplastic drug, and due to its high toxicity, the therapeutic
drug monitoring is strictly conducted in the clinical practice. The chemometric optimization …

This paper aims at covering the principal strategies based on liquid chromatography (LC) for
metabolite profiling in the field of drug discovery and development. The identification of …