Abstract The World Health Organization (WHO) classification of tumors of the hematopoietic
and lymphoid tissues was last updated in 2008. Since then, there have been numerous …

RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

Advances in genomic research and risk-directed therapy have led to improvements in the
long-term survival and quality of life outcomes of patients with childhood acute lymphoblastic …

Standardized variant curation is essential for clinical care recommendations for patients with
inherited disorders. Clinical Genome Resource (ClinGen) variant curation expert panels are …

Myelodysplastic syndrome (MDS) is clonal disorder characterized by ineffective
hematopoiesis and a tendency to evolve into acute myeloid leukemia (AML). Genetic studies …

Although inherited hematopoietic malignancies have been reported clinically since the early
twentieth century, the molecular basis for these diseases has only recently begun to be …

Myeloid neoplasms (MNs) with germline predisposition have recently been recognized as
novel entities in the latest World Health Organization (WHO) classification for MNs …

GATA2 is a zinc finger transcription factor essential for embryonic and definitive
hematopoiesis as well as lymphatic angiogenesis. GATA2 deficiency is caused by a variety …

Leukemia, the most common childhood cancer, has long been recognized to occasionally
run in families. The first clues about the genetic mechanisms underlying familial leukemia …

Childhood leukemias are heterogeneous diseases with widely differing incident rates
worldwide. As circulating tumors, childhood acute leukemias are uniquely accessible, and …