Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats

S Kohli, MV King, S Williams, A Edwards… - …, 2019 - nature.com
The pituitary neuropeptide oxytocin promotes social behavior, and is a potential adjunct
therapy for social deficits in schizophrenia and autism. Oxytocin may mediate pro-social …

Effect of early life social adversity on drug abuse vulnerability: Focus on corticotropin-releasing factor and oxytocin

MT Bardo, LR Hammerslag, SG Malone - Neuropharmacology, 2021 - Elsevier
Early life adversity can set the trajectory for later psychiatric disorders, including substance
use disorders. There are a host of neurobiological factors that may play a role in the …

Oxytocinergic manipulations in corticolimbic circuit differentially affect fear acquisition and extinction

N Lahoud, M Maroun - Psychoneuroendocrinology, 2013 - Elsevier
The oxytocinergic system promotes social behavior and reduces anxiety. The significant
roles and functional interactions of the medial prefrontal cortex and the amygdala in the …

The vagus nerve mediates the suppressing effects of peripherally administered oxytocin on methamphetamine self-administration and seeking in rats

NA Everett, AJ Turner, PA Costa, SJ Baracz… - …, 2021 - nature.com
The neuropeptide oxytocin has emerged as a promising pharmacotherapy for
methamphetamine (METH) addiction, and clinical trials of intranasal oxytocin are underway …

Peripheral oxytocin administration reduces ethanol consumption in rats

K MacFadyen, R Loveless, B DeLucca… - Pharmacology …, 2016 - Elsevier
The neuropeptide oxytocin interacts with mesolimbic dopamine neurons to mediate reward
associated with filial behaviors, but also other rewarding behaviors such as eating or taking …

Oxytocin in the nucleus accumbens core reduces reinstatement of methamphetamine‐seeking behaviour in rats

SJ Baracz, NA Everett, IS McGregor… - Addiction …, 2016 - Wiley Online Library
The psychostimulant methamphetamine (METH) is an addictive illicit drug. Systemic
administration of the neuropeptide oxytocin modulates METH‐related reward and METH …

The effect of chronic oxytocin treatment during abstinence from methamphetamine self-administration on incubation of craving, reinstatement, and anxiety

NA Everett, SJ Baracz, JL Cornish - Neuropsychopharmacology, 2020 - nature.com
Methamphetamine (METH) abuse is characterised by chronic relapse and anxiety, for which
there are no effective pharmacotherapies. Acute treatment with the neuropeptide oxytocin …

Neural mechanisms underlying incubation of methamphetamine craving: a mini-review

RD Altshuler, H Lin, X Li - Pharmacology Biochemistry and Behavior, 2020 - Elsevier
Cue-induced drug craving and seeking progressively increases during abstinence. This
“incubation of drug craving” phenomenon has been observed in both laboratory animals …

Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain

J Qi, WY Han, JY Yang, LH Wang, YX Dong… - Addiction …, 2012 - Wiley Online Library
Oxytocin (OT), a neurohypophyseal neuropeptide, affects adaptive processes of the central
nervous system. In the present study, we investigated the effects of OT on extracellular levels …

The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: Applicability of oxytocin as a pharmacotherapy

SJ Baracz, NA Everett, JL Cornish - Neuroscience & Biobehavioral …, 2020 - Elsevier
Early life trauma is strongly associated with an increased vulnerability to abuse illicit drugs
and the impairment of neural development. This includes alterations to the development of …