Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference

SJ Baracz, PI Rourke, MC Pardey, GE Hunt… - Behavioural brain …, 2012 - Elsevier
Accumulating evidence indicates that the neuropeptide oxytocin (OXY) may modulate
reward-related behavioural responses to methamphetamine (METH) administration. Limited …

Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges

X Che, J Cai, Y Liu, T Xu, J Yang, C Wu - Pharmacology & therapeutics, 2021 - Elsevier
Drug addiction is one of the leading causes of mortality worldwide. Despite great advances
were achieved in understanding the neurobiology of drug addiction, the therapeutic options …

Role of oxytocin and vasopressin in neuropsychiatric disorders: therapeutic potential of agonists and antagonists

V Cid-Jofré, M Moreno, M Reyes-Parada… - International Journal of …, 2021 - mdpi.com
Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically
associated with their regulatory role in reproduction, water homeostasis, and social …

Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin

V Bisagno, JL Cadet - Behavioural pharmacology, 2014 - journals.lww.com
Stress sensitivity and sex are predictive factors for the development of neuropsychiatric
disorders. Life stresses are not only risk factors for the development of addiction but also are …

A role for oxytocin in the etiology and treatment of schizophrenia

ME Rich, HK Caldwell - Frontiers in endocrinology, 2015 - frontiersin.org
Schizophrenia is a chronic debilitating neuropsychiatric disorder estimated to affect 51
million people worldwide. Several symptom domains characterize schizophrenia, including …

Oxytocin prevents the increase of cocaine-related responses produced by social defeat

C Ferrer-Pérez, A Castro-Zavala, MÁ Luján… - …, 2019 - Elsevier
The neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and
emotional behaviors. OXT plays a role in stress response and in drug reward, but to date no …

The nonpeptide oxytocin receptor agonist WAY 267,464: Receptor‐binding profile, prosocial effects and distribution of c‐Fos expression in adolescent rats

C Hicks, W Jorgensen, C Brown… - Journal of …, 2012 - Wiley Online Library
Previous research suggests that the nonpeptide oxytocin receptor (OTR) agonist WAY
267,464 may only partly mimic the effects of oxytocin in rodents. The present study further …

Oxytocin, tolerance, and the dark side of addiction

CA Pedersen - International review of neurobiology, 2017 - Elsevier
Substance use disorders blight the lives of millions of people and inflict a heavy financial
burden on society. There is a compelling need for new pharmacological treatments as …

Regionally specific effects of oxytocin on reinstatement of cocaine seeking in male and female rats

RA Weber, CN Logan, KC Leong, J Peris… - International Journal …, 2018 - academic.oup.com
Background Oxytocin reduces cued reinstatement of cocaine seeking in male and female
rats, but the underlying neurobiology has not been uncovered. The majority of effort on this …

The neurocircuitry involved in oxytocin modulation of methamphetamine addiction

SJ Baracz, JL Cornish - Frontiers in neuroendocrinology, 2016 - Elsevier
The role of oxytocin in attenuating the abuse of licit and illicit drugs, including the
psychostimulant methamphetamine, has been examined with increased ferocity in recent …