Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

P Georgiou, P Zanos, JA Garcia-Carmona, S Hourani… - …, 2016 - Elsevier
The major challenge in treating methamphetamine addicts is the maintenance of a drug free-
state since they experience negative emotional symptoms during abstinence, which may …

Oxytocin and addiction: potential glutamatergic mechanisms

M Sundar, D Patel, Z Young, KC Leong - International journal of …, 2021 - mdpi.com
Recently, oxytocin (OXT) has been investigated for its potential therapeutic role in addiction.
OXT has been found to diminish various drug-seeking and drug-induced behaviors …

Adolescent pre‐treatment with oxytocin protects against adult methamphetamine‐seeking behavior in female rats

C Hicks, JL Cornish, SJ Baracz, A Suraev… - Addiction …, 2016 - Wiley Online Library
The neuropeptide oxytocin (OT), given acutely, reduces self‐administration of the
psychostimulant drug methamphetamine (METH). Additionally, chronic OT administration to …

Chronic methamphetamine treatment induces oxytocin receptor up-regulation in the amygdala and hypothalamus via an adenosine A2A receptor-independent …

P Zanos, SR Wright, P Georgiou, JH Yoo… - Pharmacology …, 2014 - Elsevier
There is mounting evidence that the neuropeptide oxytocin is a possible candidate for the
treatment of drug addiction. Oxytocin was shown to reduce methamphetamine self …

The role of oxytocin and vasopressin in drug-induced reward—implications for social and non-social factors

O Wronikowska-Denysiuk, W Mrozek, B Budzyńska - Biomolecules, 2023 - mdpi.com
Drug abuse is a worldwide problem that leads to negative physical, mental, and economic
consequences. Although pharmacological strategies for drug addiction management have …

[HTML][HTML] Compulsive methamphetamine taking and abstinence in the presence of adverse consequences: Epigenetic and transcriptional consequences in the rat brain

JL Cadet, R Patel, S Jayanthi - Pharmacology Biochemistry and Behavior, 2019 - Elsevier
Methamphetamine addiction is characterized by compulsive binges of drug intake despite
adverse life consequences. A model of methamphetamine self-administration that includes …

Complexity of oxytocin׳ s effects in a chronic cocaine dependent population

MR Lee, M Glassman, B King-Casas, DL Kelly… - European …, 2014 - Elsevier
Behavioral and neuroplastic changes occurring in the development of addiction parallel
those that occur in social bonding. This has led to speculation that drugs of abuse co-opt …

Sign tracking predicts cue-induced but not drug-primed reinstatement to methamphetamine seeking in rats: Effects of oxytocin treatment

NA Everett, HA Carey, JL Cornish… - Journal of …, 2020 - journals.sagepub.com
Background: The incentive sensitisation theory of addiction posits that drug-associated
stimuli become imbued with incentive motivational properties, driving pathological drug …

Oxytocin: parallel processing in the social brain?

G Dölen - Journal of neuroendocrinology, 2015 - Wiley Online Library
Early studies attempting to disentangle the network complexity of the brain exploited the
accessibility of sensory receptive fields to reveal circuits made up of synapses connected …

Oxytocin increases physiological linkage during group therapy for methamphetamine use disorder: a randomized clinical trial

KR Thorson, SM McKernan, TV West, JD Woolley… - Scientific reports, 2021 - nature.com
Patients and psychotherapists often exhibit behavioral, psychological, and physiological
similarity. Here, we test whether oxytocin—a neuropeptide that can enhance expressivity …