Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Introduction Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disorder with an
incidence of 1 in 14–17,000 male births, caused by pathogenic variants within the ABCD1 …

The adrenal cortex undergoes multiple structural and functional rearrangements to satisfy
the systemic needs for steroids during fetal life, postnatal development, and adulthood. A …

Adrenal insufficiency (AI) is a potentially life-threatening condition that can be difficult to
diagnose, especially if it is not considered as a potential cause of a child's clinical …

In 2009, cerebral adrenoleukodystrophy (c-ALD) became the first brain disease to be treated
with lentiviral (LV)-based hematopoietic stem cell gene therapy with the ABCD1 gene in four …

ATP-binding cassette (ABC) transporters play a crucial role for the efflux of a wide range of
substrates across different cellular membranes. In the central nervous system (CNS), ABC …

Oligodendrocytes are the myelinating cells in the CNS and multiple sclerosis (MS) is a
demyelinating disorder that is characterized by progressive loss of myelin. Although …

X-linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disease caused by
pathogenic variants in ABCD1 resulting in defective peroxisomal oxidation of very long …

Adrenal insufficiency (AI) is a severe endocrine disorder characterized by insufficient
glucocorticoid (GC) and/or mineralocorticoid (MC) secretion by the adrenal glands, due to …

An update on the diagnosis and treatment of adrenoleukodystr... : Current Opinion in
Endocrinology, Diabetes and Obesity An update on the diagnosis and treatment of …