Emerging role of cancer-associated fibroblasts in progression and treatment of hepatocellular carcinoma

H Akkız - International Journal of Molecular Sciences, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and the
fourth leading cause of cancer-related death globally. Tumor cells recruit and remodel …

Secretome of stromal cancer-associated fibroblasts (CAFs): Relevance in cancer

D Mishra, D Banerjee - Cells, 2023 - mdpi.com
The cancer secretome reflects the assortment of proteins released by cancer cells.
Investigating cell secretomes not only provides a deeper knowledge of the healthy and …

Cancer-associated fibroblasts in gastrointestinal cancers: unveiling their dynamic roles in the tumor microenvironment

NN Al-Bzour, AN Al-Bzour, OE Ababneh… - International Journal of …, 2023 - mdpi.com
Gastrointestinal cancers are highly aggressive malignancies with significant mortality rates.
Recent research emphasizes the critical role of the tumor microenvironment (TME) in these …

Impact of ACSL4 on the prognosis of hepatocellular carcinoma: Association with cancer‐associated fibroblasts and the tumour immune microenvironment

K Toshida, S Itoh, N Iseda, T Tomiyama… - Liver …, 2024 - Wiley Online Library
Abstract Background & Aims Recently, the association between hepatocellular carcinoma
(HCC) and ferroptosis has been the focus of much attention. The expression of long chain …

Unveiling Anoikis‐related genes: A breakthrough in the prognosis of bladder cancer

S Jiang, X Yang, Y Lin, Y Liu, LJ Tran… - The Journal of Gene …, 2024 - Wiley Online Library
Background Bladder cancer (BLCA) is a prevalent malignancy worldwide. Anoikis remains a
new form of cell death. It is necessary to explore Anoikis‐related genes in the prognosis of …

[HTML][HTML] Single-cell and bulk RNA sequencing reveal cancer-associated fibroblast heterogeneity and a prognostic signature in prostate cancer

W Liu, M Wang, M Wang, M Liu - Medicine, 2023 - journals.lww.com
Abstract Cancer-associated fibroblasts (CAFs), the central players in the tumor
microenvironment (TME), can promote tumor progression and metastasis via various …

Ang-1 and VEGF: central regulators of angiogenesis

Y Zhao, B Yu, Y Wang, S Tan, Q Xu, Z Wang… - Molecular and Cellular …, 2024 - Springer
Abstract Angiopoietin-1 (Ang-1) and Vascular Endothelial Growth Factor (VEGF) are central
regulators of angiogenesis and are often inactivated in various cardiovascular diseases …

Identification and validation of cancer-associated fibroblast-related subtypes and the prognosis model of biochemical recurrence in prostate cancer based on single …

T Li, Z Zhou, Z Xie, X Fan, Y Zhang, Y Zhang… - Journal of Cancer …, 2023 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs) are an essential component of
the tumor immune microenvironment that are involved in extracellular matrix (ECM) …

[HTML][HTML] Integrated analysis of single-cell and bulk RNA-seq establishes a novel signature for prediction in gastric cancer

F Wen, X Guan, HX Qu, XJ Jiang - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Single-cell sequencing technology provides the capability to analyze
changes in specific cell types during the progression of disease. However, previous single …

[HTML][HTML] Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on …

X Sun, F Meng, M Nong, H Fang, C Lu, Y Wang… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Background: Lung adenocarcinoma (LUAD) is one of the leading malignant cancers.
Aggrephagy plays a critical role in key genetic events for various cancers; yet, how …