[HTML][HTML] Hepatitis C virus infection: host–virus interaction and mechanisms of viral persistence

DGI Chigbu, R Loonawat, M Sehgal, D Patel, P Jain - Cells, 2019 - mdpi.com
Hepatitis C (HCV) is a major cause of liver disease, in which a third of individuals with
chronic HCV infections may develop liver cirrhosis. In a chronic HCV infection, host immune …

[HTML][HTML] Natural killer cells in viral hepatitis

B Rehermann - Cellular and molecular gastroenterology and …, 2015 - Elsevier
Natural killer (NK) cells are traditionally regarded as first-line effectors of the innate immune
response, but they also have a distinct role in chronic infection. Here, we review the role of …

Impact of HIV on host-virus interactions during early hepatitis C virus infection

M Danta, N Semmo, P Fabris, D Brown… - The Journal of …, 2008 - academic.oup.com
Background. Human immunodeficiency virus (HIV) may influence the outcome and natural
history of hepatitis C virus (HCV) infection through an impact on acute HCV-specific T cell …

Immunogenicity of CIGB‐230, a therapeutic DNA vaccine preparation, in HCV‐chronically infected individuals in a Phase I clinical trial

L Alvarez‐Lajonchere, NH Shoukry, B Gra… - Journal of viral …, 2009 - Wiley Online Library
Hepatitis C virus (HCV) is a worldwide health problem. No vaccine is available against this
pathogen and therapeutic treatments currently in use are of limited efficacy. In the present …

Functional exhaustion of CD4+ T lymphocytes during primary cytomegalovirus infection

P Antoine, V Olislagers, A Huygens… - The Journal of …, 2012 - journals.aai.org
Human CMV establishes lifelong persistence after primary infection. Chronic CMV infection
is associated with intermittent viral reactivation inducing high frequencies of CD4+ T …

[HTML][HTML] CD4+ T cell responses in hepatitis C virus infection

N Semmo, P Klenerman - World journal of gastroenterology: WJG, 2007 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) infection is a major cause of liver damage, with virus-induced end-
stage disease such as liver cirrhosis and hepatocellular carcinoma resulting in a high rate of …

[HTML][HTML] HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway

Q Zhang, Y Wang, N Zhai, H Song, H Li, Y Yang, T Li… - Scientific reports, 2016 - nature.com
Hepatitis C virus (HCV) establishes persistent infection in most infected patients, and
eventually causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma in some …

[HTML][HTML] Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation

E Patsenker, P Sachse, A Chicca, MS Gachet… - International journal of …, 2015 - mdpi.com
The endocannabinoid (EC) system is implicated in many chronic liver diseases, including
hepatitis C viral (HCV) infection. Cannabis consumption is associated with fibrosis …

Cellular immune responses to HCV core increase and HCV RNA levels decrease during successful antiretroviral therapy

J Rohrbach, N Robinson, G Harcourt, E Hammond… - Gut, 2010 - gut.bmj.com
Background Hepatitis C virus (HCV) infection is a major cause of morbidity in HIV infected
individuals. Coinfection with HIV is associated with diminished HCV-specific immune …

Cellular immune responses during high-dose interferon-α induction therapy for hepatitis C virus infection

E Barnes, HC Gelderblom, I Humphreys… - The Journal of …, 2009 - academic.oup.com
Background The effect that high-dose interferon (IFN)–α induction therapy for hepatitis C
virus (HCV) infection has on cellular immune responses is currently unknown Methods Thirty …