Radiotherapy combined with immunotherapy: the dawn of cancer treatment
Z Zhang, X Liu, D Chen, J Yu - Signal Transduction and Targeted …, 2022 - nature.com
Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …
Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts
D Averbeck, C Rodriguez-Lafrasse - International journal of molecular …, 2021 - mdpi.com
Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …
damage and their management by repair mechanisms. However, molecular biology studies …
The interplay between the DNA damage response and ectonucleotidases modulates tumor response to therapy
J Stagg, E Golden, E Wennerberg, S Demaria - Science immunology, 2023 - science.org
The extracellular nucleoside adenosine reduces tissue inflammation and is generated by
irreversible dephosphorylation of adenosine monophosphate (AMP) mediated by the …
irreversible dephosphorylation of adenosine monophosphate (AMP) mediated by the …
Radiotherapy and the immune system: More than just immune suppression
Radiotherapy (RT) is still one of the standard cancer therapies, with up to two third of all
cancer patients with solid tumors being irradiated in the course of their disease. The aim of …
cancer patients with solid tumors being irradiated in the course of their disease. The aim of …
Charting roadmaps towards novel and safe synergistic immunotherapy combinations
MF Sanmamed, P Berraondo, ME Rodriguez-Ruiz… - Nature Cancer, 2022 - nature.com
Checkpoint inhibitor-based cancer immunotherapy is often combined in the clinic with other
immunotherapy strategies, targeted therapies, chemotherapy or standard-of-care treatments …
immunotherapy strategies, targeted therapies, chemotherapy or standard-of-care treatments …
Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review
L Tagliaferri, V Lancellotta, B Fionda… - Human Vaccines & …, 2022 - Taylor & Francis
Melanoma is an extremely aggressive tumor and is considered to be an extremely
immunogenic tumor because compared to other cancers it usually presents a well …
immunogenic tumor because compared to other cancers it usually presents a well …
Exosomal PD-L1: new insights into tumor immune escape mechanisms and therapeutic strategies
K Zhou, S Guo, F Li, Q Sun, G Liang - Frontiers in Cell and …, 2020 - frontiersin.org
As a classical immune checkpoint molecule, PD-L1 on the surface of tumor cells plays a
pivotal role in tumor immunosuppression, primarily by inhibiting the antitumor activities of T …
pivotal role in tumor immunosuppression, primarily by inhibiting the antitumor activities of T …
Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment
D Maggiorani, O Le, V Lisi, S Landais… - Nature …, 2024 - nature.com
The potential of immune checkpoint inhibitors (ICI) may be limited in situations where
immune cell fitness is impaired. Here, we show that the efficacy of cancer immunotherapies …
immune cell fitness is impaired. Here, we show that the efficacy of cancer immunotherapies …
Tumor immunology and immunotherapy of non-small-cell lung cancer
T Cascone, J Fradette… - Cold Spring …, 2021 - perspectivesinmedicine.cshlp.org
Historically, non-small-cell lung cancer (NSCLC) has been regarded as a nonimmunogenic
tumor; however, recent studies have shown that NSCLCs are among the most responsive …
tumor; however, recent studies have shown that NSCLCs are among the most responsive …
[HTML][HTML] Radiation-induced PD-L1 expression in tumor and its microenvironment facilitates cancer-immune escape: a narrative review
NH Wang, Z Lei, HN Yang, Z Tang… - Annals of …, 2022 - ncbi.nlm.nih.gov
Methods We performed a narrative review of the literature in the PubMed database. The
research string comprised various combinations of “radiotherapy”,“programmed death …
research string comprised various combinations of “radiotherapy”,“programmed death …