Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

The extracellular nucleoside adenosine reduces tissue inflammation and is generated by
irreversible dephosphorylation of adenosine monophosphate (AMP) mediated by the …

Radiotherapy (RT) is still one of the standard cancer therapies, with up to two third of all
cancer patients with solid tumors being irradiated in the course of their disease. The aim of …

Checkpoint inhibitor-based cancer immunotherapy is often combined in the clinic with other
immunotherapy strategies, targeted therapies, chemotherapy or standard-of-care treatments …

Melanoma is an extremely aggressive tumor and is considered to be an extremely
immunogenic tumor because compared to other cancers it usually presents a well …

As a classical immune checkpoint molecule, PD-L1 on the surface of tumor cells plays a
pivotal role in tumor immunosuppression, primarily by inhibiting the antitumor activities of T …

The potential of immune checkpoint inhibitors (ICI) may be limited in situations where
immune cell fitness is impaired. Here, we show that the efficacy of cancer immunotherapies …

Historically, non-small-cell lung cancer (NSCLC) has been regarded as a nonimmunogenic
tumor; however, recent studies have shown that NSCLCs are among the most responsive …

Methods We performed a narrative review of the literature in the PubMed database. The
research string comprised various combinations of “radiotherapy”,“programmed death …