Oxidative stress, a cytopathic outcome of excessive generation of ROS and the repression of
antioxidant defense system for ROS elimination, is involved in the pathogenesis of multiple …

Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …

The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However,
only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Background Dapagliflozin is a sodium-glucose cotransporter-2 inhibitor approved for the
treatment of type 2 diabetes. We aimed to assess the efficacy and safety of dapagliflozin as …

Epigenetic pathways play a pivotal role in the development and function of the immune
system. Over the last decade, a growing body of studies has been published out seeking to …

Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …

This review covers the epidemiology, pathophysiology, clinical features, diagnosis, and
management of diabetic gastroparesis, and more broadly diabetic gastroenteropathy, which …

Significance: A growing body of clinical and experimental evidence has challenged the
traditional understanding that only the adaptive immune system can mount immunological …