In many parts of the world the commonest serious opportunistic infection that occurs in HIV-1
infected persons is tuberculosis (TB). HIV-1 co-infection modifies the natural history and …

Background Mycobacterium tuberculosis (Mtb) infection may cause overt disease or remain
latent. Interferon gamma release assays (IGRAs) detect Mtb infection, both latent infection …

Although interferon-γ release assays (IGRAs) are intended for diagnosing latent tuberculosis
(TB), we hypothesised that in a high-burden setting: 1) the magnitude of the response when …

Background The performance of the tuberculosis specific Interferon Gamma Release Assays
(IGRAs) has not been sufficiently documented in tuberculosis-and HIV-endemic settings …

Background The measurement of Interferon gamma or Interferon gamma inducible protein
(IP)-10 in antigen stimulated blood samples is suggested as an alternative method for latent …

Infection with HIV is the greatest risk factor for tuberculosis (TB) in Africa. Tuberculin skin test
(TST), QuantiFERON-TB Gold In-Tube (QFT-G-IT) and T-Spot. TB assays were performed in …

BACKGROUND: The clinical manifestations of extrapulmonary tuberculosis (E-TB) vary
according to site of disease, so we tested the hypothesis that IFN-γ producing T-cell …

SETTING AND OBJECTIVE: To investigate the sensitivity of the new interferon-gamma
release assay (IGRA), QuantiFERON®-TB Gold Plus (QFT-Plus), for active TB (used as a …

Rationale: Current tools for the rapid diagnosis of tuberculous meningitis (TBM) are
suboptimal. We evaluated the clinical utility of a quantitative RD-1 IFN-γ T-cell enzyme …

Interferon-gamma release assays (IGRAs) represent the first new tool to diagnose latent
tuberculosis infection for more than 100 years. They have advantages over the traditional …