100 years of Mycobacterium bovis bacille Calmette-Guérin
Summary Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …
Key advances in vaccine development for tuberculosis—Success and challenges
Breakthrough findings in the clinical and preclinical development of tuberculosis (TB)
vaccines have galvanized the field and suggest, for the first time since the development of …
vaccines have galvanized the field and suggest, for the first time since the development of …
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects
Regenerative stem cell–like memory (TSCM) CD8+ T cells persist longer and produce
stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces TSCM that have …
stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces TSCM that have …
Research advances for virus-vectored tuberculosis vaccines and latest findings on tuberculosis vaccine development
Z Hu, SH Lu, DB Lowrie, XY Fan - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB), caused by respiratory infection with Mycobacterium tuberculosis, remains
a major global health threat. The only licensed TB vaccine, the one-hundred-year-old Bacille …
a major global health threat. The only licensed TB vaccine, the one-hundred-year-old Bacille …
A century of BCG: Impact on tuberculosis control and beyond
BCG turns 100 this year and while it might not be the perfect vaccine, it has certainly
contributed significantly towards eradication and prevention of spread of tuberculosis (TB) …
contributed significantly towards eradication and prevention of spread of tuberculosis (TB) …
Tuberculosis in times of COVID-19
The COVID-19 pandemic has caused widespread disruptions to tuberculosis (TB) care and
service delivery in 2020, setting back progress in the fight against TB by several years. As …
service delivery in 2020, setting back progress in the fight against TB by several years. As …
BCG as a case study for precision vaccine development: lessons from vaccine heterogeneity, trained immunity, and immune ontogeny
A Angelidou, J Diray-Arce, MG Conti… - Frontiers in …, 2020 - frontiersin.org
Vaccines have been traditionally developed with the presumption that they exert identical
immunogenicity regardless of target population and that they provide protection solely …
immunogenicity regardless of target population and that they provide protection solely …
Effectiveness of booster BCG vaccination in preventing Covid-19 infection
lradj Amirlak, R Haddad, JD Hardy… - Human Vaccines & …, 2021 - Taylor & Francis
The evidence that BCG (bacille Calmette-Guerin) vaccine may increase the ability of the
immune system to fight off pathogens other than tuberculosis has been studied in the past …
immune system to fight off pathogens other than tuberculosis has been studied in the past …
A perspective on the success and failure of BCG
P Kumar - Frontiers in Immunology, 2021 - frontiersin.org
TB continues to be one of the major public health threats. BCG is the only available vaccine
against TB and confers significant protection against the childhood disease. However, the …
against TB and confers significant protection against the childhood disease. However, the …
Revaccination with Bacille Calmette-Guérin (BCG) is associated with an increased risk of abscess and lymphadenopathy
P Villanueva, U Wadia, N Crawford, NL Messina… - NPJ vaccines, 2022 - nature.com
The reported frequency and types of adverse events following initial vaccination and
revaccination with Bacille Calmette-Guérin (BCG) varies worldwide. Using active …
revaccination with Bacille Calmette-Guérin (BCG) varies worldwide. Using active …