Cardiac function is a dynamic process that must adjust efficiently to the immediate demands
of physical state and activity. So too, the metabolic support of cardiac function is a dynamic …

G protein-coupled receptor (GPCR) kinase 2 (GRK2) expression and activity are elevated
early on in response to several forms of cardiovascular stress and are a hallmark of heart …

Atrial natriuretic peptide (ANP) has been considered to exert an essential role as a cardiac
secretory hormone in the regulation of hemodynamic homeostasis. As the research …

Brown adipose tissue (BAT) is correlated to cardiovascular health in rodents and humans,
but the physiological role of BAT in the initial cardiac remodeling at the onset of stress is …

Heart failure with preserved ejection fraction (HFpEF) is highly prevalent, accounting for
50% of all heart failure patients, and is associated with significant mortality. Sodium-glucose …

Background—Substrate utilization in tissues with high energetic requirements could play an
important role in cardiometabolic disease. Current techniques to assess energetics are …

Circulation. 2020; 142: e36–e37. DOI: 10.1161/CIRCULATIONAHA. 120.048259 July 21,
2020 e37 the mouse model of heart failure with diet-induced or genetically inherited obesity …

Cardiac surgery has undergone a remarkable growth and expansion in the past decades,
allowing research to focus on perioperative homeostatic disruption. Cardiac surgery always …

Pathological stress on the heart, as occurs during chronic pressure overload, resulting from
either hypertension in humans or aortic constriction in animal models, induces a well-known …

Cardiac hypertrophy is a compensatory response to overcome the increased demands of
the pressure-overload induced heart (Tardiff 2006). However, prolonged hypertrophy …