Chemokines direct leukocyte trafficking and positioning within tissues, thus playing critical
roles in regulating immune responses and inflammation. The chemokine system is complex …

Hepatitis C virus (HCV) is a leading cause of chronic liver disease that can progress to
cirrhosis and/or hepatocellular carcinoma. Intrahepatic inflammation and liver cell injury are …

The central role of T cell activation in hepatocellular injury has been well documented. In this
article, we provide evidence suggesting that T cells may also play a protective role in liver …

BACKGROUND/AIMS: Prediction of sustained virological response (SVR) during treatment
would allow clinicians to identify patients most likely to benefit from therapy. METHODS …

Genetic polymorphisms near IL28B are associated with spontaneous and treatment‐
induced clearance of hepatitis C virus (HCV), two processes that require the appropriate …

BACKGROUND/AIMS: The fate of intrahepatic NK cell subsets in the course of HCV and
HBV infections is not clearly understood. METHODS: Blood and intrahepatic CD56+ NK cell …

This study investigated the response of acute lymphoblastic leukaemia (ALL) cells to Wnt
proteins. Accumulation of β‐catenin was measured by Western blotting and …

Chronic infection with the hepatitis C virus, a noncytopathic hepatotropic RNA virus, affects
over 170 million people worldwide. In the majority of cases, neither the early innate immune …

The liver has been generally considered an organ prone to tolerance induction and
maintenance. However, whether and how the unique liver microenvironment contributes to …

Chemokines produced in the liver during hepatitis C virus (HCV) infection induce migration
of activated T cells from the periphery to infected parenchyma. The milieu of chemokines …